Carpagnano Giovanna E, Lacedonia Donato, Crisetti Elisabetta, Martinelli Domenico, Foschino-Barbaro Maria P
Institute of Respiratory Diseases, Department of Medical and Surgical Sciences, University of Foggia, Italy.
J Cancer. 2016 Nov 25;7(15):2266-2269. doi: 10.7150/jca.15921. eCollection 2016.
Our research group demonstrated, in a precedent study, the prognostic power of the 3p microsatellites alterations (MAs) detectable in exhaled breath condensate (EBC) in NSCLC patients. The analysis of genetic markers in the EBC might have precious clinical and economic consequences when inserted in diagnostic and follow up programs for lung cancer. The aim of this study was to evaluate the prognostic value of a new panel of MAs in the EBC of patients with NSCLC. We enrolled 45 NSCLC patients during a period of 36 months and the follow-up period was 156 weeks. We analyzed MAs for eight markers in EBC samples: D3S2338, D3S1266, D3S1300, D3S1304, D3S1289, D5S2094, D3S1313, and AFMa305ye1. Our study showed that the presence of more than 2 simultaneous MAs reduces outcome in NSCLC patients. The new panel of eight microsatellites markers proposed in EBC samples could have a potential clinical role in assessing survival in lung cancer patients.
我们的研究小组在前一项研究中证明了在非小细胞肺癌（NSCLC）患者呼出的呼出气冷凝物（EBC）中可检测到的3p微卫星改变（MA）的预后能力。当将EBC中的基因标记物纳入肺癌的诊断和随访程序时，其分析可能会产生宝贵的临床和经济影响。本研究的目的是评估一组新的MA在NSCLC患者EBC中的预后价值。我们在36个月内招募了45例NSCLC患者，随访期为156周。我们分析了EBC样本中八个标记物的MA：D3S2338、D3S1266、D3S1300、D3S1304、D3S1289、D5S2094、D3S1313和AFMa305ye1。我们的研究表明，同时存在超过2种MA会降低NSCLC患者的预后。EBC样本中提出的新的八个微卫星标记物组可能在评估肺癌患者的生存方面具有潜在的临床作用。
