一种对……具有抗真菌活性的类肽的发现与特性研究
Discovery and Characterization of a Peptoid with Antifungal Activity against .
作者信息
Corson Ashley E, Armstrong Scott A, Wright Matthew E, McClelland Erin E, Bicker Kevin L
机构信息
Department of Chemistry and Department of Biology, Middle Tennessee State University , 1301 East Main Street, Murfreesboro, Tennessee 37132, United States.
出版信息
ACS Med Chem Lett. 2016 Oct 3;7(12):1139-1144. doi: 10.1021/acsmedchemlett.6b00338. eCollection 2016 Dec 8.
Abstract
Studies show there is an increasing rate of fungal infections, especially in immunocompromised patients and treatments for fungal genera, such as , , and , carry significant cytotoxicity with an increasing prevalence of antifungal resistance. We have previously reported a high-throughput assay for identifying peptoids with antimicrobial properties from combinatorial libraries. Here we report the application of this assay in identifying a peptoid with antifungal properties against . Termed AEC5, this peptoid has comparable potency to existing clinical antifungal agents, excellent stability, and minimal cytotoxicity in mammalian cells.
摘要
研究表明，真菌感染率正在上升，尤其是在免疫功能低下的患者中，并且针对真菌属（如 、 和 ）的治疗具有显著的细胞毒性，同时抗真菌耐药性的患病率也在增加。我们之前报道了一种高通量检测方法，用于从组合文库中鉴定具有抗菌特性的类肽。在此，我们报告该检测方法在鉴定一种对 具有抗真菌特性的类肽中的应用。这种名为AEC5的类肽与现有的临床抗真菌药物具有相当的效力，具有出色的稳定性，并且在哺乳动物细胞中的细胞毒性极小。
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