Silva-Brenes Diana, Delgado Loruhama, Rivera José M
Department of Chemistry and Molecular Sciences Research Center, University of Puerto Rico at Río Piedras, San Juan, 00926, Puerto Rico.
Org Biomol Chem. 2017 Jan 25;15(4):782-786. doi: 10.1039/c6ob02586b.
We report the synthesis and self-assembly of two lipophilic 2'-deoxyguanosine (G) derivatives whose fluorescence intensity is modulated by self-assembly into supramolecular G-quadruplexes (SGQs). Whereas both derivatives self-assemble isostructurally, one shows up to 100% emission enhancement while the other shows an initial enhancement, followed by 10% quenching. Thus, the rotational restrictions resulting from self-assembly are enough to induce significant changes in emission, but it is critical to consider the specific interactions between fluorophores since they will determine the ultimate emission signature. These findings could open the door to the development of luminescent supramolecular sensors and probes.
我们报道了两种亲脂性2'-脱氧鸟苷（G）衍生物的合成与自组装，其荧光强度通过自组装成超分子G-四链体（SGQ）来调节。尽管两种衍生物以同构方式自组装，但一种显示出高达100%的发射增强，而另一种则显示出初始增强，随后淬灭10%。因此，自组装产生的旋转限制足以引起发射的显著变化，但考虑荧光团之间的特定相互作用至关重要，因为它们将决定最终的发射特征。这些发现可能为发光超分子传感器和探针的开发打开大门。
