Fricker-Hidalgo H, L'Ollivier C, Bosson C, Imbert S, Bailly S, Dard C, Piarroux R, Paris L, Pelloux H
Laboratory of Parasitology and Mycology, Grenoble University Hospital and Grenoble Alpes University, CS10217, 38043, Grenoble Cedex 9, France.
Laboratory of Parasitology and Mycology, La Timone University Hospital and UMR MD3 IP-TPT Aix Marseille University, Marseille, France.
Eur J Clin Microbiol Infect Dis. 2017 May;36(5):847-852. doi: 10.1007/s10096-016-2870-y. Epub 2016 Dec 19.
Initial results with the Elecsys Toxo IgG Avidity assay showed some potential for interpretation of a very low or very high index result. We aimed to examine these new insights into interpretation using a large panel of serum samples and to define the optimal thresholds. A total of 741 patient serum samples with known date of infection (from a few weeks to more than 9 months after infection), were analysed with the Elecsys Toxo IgG Avidity assay. Values ≥80% (threshold defined by the manufacturer) were reported in 289 sera; 288 sera were sampled more than 4 months after infection. Thus, avidity values ≥80% excluded an infection less than 4 months. Avidity values ≥90% were reported in 112 sera sampled more than 9 months after infection. Thus, avidity values ≥90% excluded infection less than 9 months. Moreover avidity values ≤15% were reported in the 62 sera sampled less than 3 months after infection. Thus avidity values ≤15% excluded infection more than 3 months.
Elecsys弓形虫IgG亲和力检测的初步结果显示，对于极低或极高指数结果的解读具有一定潜力。我们旨在使用大量血清样本检验这些关于解读的新见解，并确定最佳阈值。使用Elecsys弓形虫IgG亲和力检测对总共741份已知感染日期（感染后数周至9个多月）的患者血清样本进行了分析。289份血清报告的值≥80%（由制造商定义的阈值）；288份血清是在感染后4个月以上采集的。因此，亲和力值≥80%排除了感染时间少于4个月的情况。112份在感染后9个月以上采集的血清报告的亲和力值≥90%。因此，亲和力值≥90%排除了感染时间少于9个月的情况。此外，62份在感染后不到3个月采集的血清报告的亲和力值≤15%。因此，亲和力值≤15%排除了感染时间超过3个月的情况。
