Mattei Lorenza, Longo Antonia, Di Puccio Francesca, Ciulli Enrico, Marchetti Stefano
Department of Civil and Industrial Engineering, University of Pisa, Largo Lucio Lazzarino 2, 56126, Pisa, Italy.
Department of Translational Research and of New Surgical and Medical Technologies, University of Pisa, Pisa, Italy.
Ann Biomed Eng. 2017 Apr;45(4):1111-1121. doi: 10.1007/s10439-016-1769-1. Epub 2016 Dec 19.
A bone healing assessment is crucial for the successful treatment of fractures, particularly in terms of the timing of support devices. However, in clinical practice, this assessment is only made qualitatively through bone manipulation and X-rays, and hence cannot be repeated as often as might be required. The present study reconsiders the quantitative method of frequency response analysis for healing assessments, and specifically for fractures treated with an external fixator. The novelty consists in the fact that bone excitation and response are achieved through fixator pins, thus overcoming the problem of transmission through soft-tissues and their damping effect. The main objective was to develop and validate a test procedure in order to characterize the treated bone. More than 80 tests were performed on a tibia phantom alone, a phantom with pins, and a phantom with a complete fixator. Different excitation techniques and input-output combinations were compared. The results demonstrated the effectiveness of a procedure based on impact tests using a micro-hammer. Pins and fixator were demonstrated to influence the frequency response of the phantom by increasing the number of resonant frequencies. This procedure will be applied in future studies to monitor healing both in in vitro and in vivo conditions.
骨愈合评估对于骨折的成功治疗至关重要,特别是在确定支撑装置的使用时机方面。然而,在临床实践中,这种评估仅通过骨触诊和X射线进行定性,因此无法根据需要频繁重复。本研究重新审视了用于愈合评估的频率响应分析定量方法,特别是针对使用外固定器治疗的骨折。其新颖之处在于通过固定针实现骨激发和响应,从而克服了软组织传递及其阻尼效应的问题。主要目标是开发并验证一种测试程序,以表征治疗后的骨骼。仅对胫骨模型、带针模型和带完整固定器的模型进行了80多次测试。比较了不同的激发技术和输入-输出组合。结果证明了基于微锤冲击试验的程序的有效性。结果表明,针和固定器会通过增加共振频率的数量来影响模型的频率响应。该程序将应用于未来的研究中,以监测体外和体内条件下的愈合情况。