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神经重症监护医生眼中的寨卡病毒病

Zika Virus Disease for the Neurointensivist.

作者信息

Pastula Daniel M, Durrant Julia C, Smith Daniel E, Beckham J David, Tyler Kenneth L

机构信息

Neuro-Infectious Diseases Group, Department of Neurology and Division of Infectious Diseases, University of Colorado Denver, 12401 East 17th Avenue, Mailstop L950, Room 486, Aurora, CO, 80045, USA.

Department of Neurology, Oregon Health and Sciences University, Portland, OR, USA.

出版信息

Neurocrit Care. 2017 Jun;26(3):457-463. doi: 10.1007/s12028-016-0333-z.

Abstract

Zika virus (ZIKV) is a mosquito-borne and sexually transmitted flavivirus currently spreading throughout the Pacific and Western Hemisphere. ZIKV infection is often either asymptomatic or causes a self-limiting illness with symptoms such as rash, fever, myalgia, arthralgia, headache, or conjunctivitis. Rarely, ZIKV infection has been associated with conditions such as severe thrombocytopenia, microcephaly and other developmental abnormalities, acute polyneuropathy/Guillain-Barré syndrome, myelitis, meningoencephalitis, transient encephalopathy, provoked seizures, and various ophthalmologic conditions. Optimal treatment of these ZIKV-associated conditions is currently unclear and is largely guided by expert opinion or case reports/series. Further studies are needed to establish best treatment practices. This review concentrates on caring by neurointensivists for the patient affected with Zika virus-expected to flare up again in the summer.

摘要

寨卡病毒(ZIKV)是一种通过蚊子传播和性传播的黄病毒,目前正在太平洋地区和西半球传播。寨卡病毒感染通常无症状,或引起一种自限性疾病,症状包括皮疹、发热、肌痛、关节痛、头痛或结膜炎。寨卡病毒感染很少与严重血小板减少症、小头畸形和其他发育异常、急性多发性神经病/吉兰-巴雷综合征、脊髓炎、脑膜脑炎、短暂性脑病、诱发性癫痫以及各种眼科疾病等情况相关。目前尚不清楚这些与寨卡病毒相关疾病的最佳治疗方法,很大程度上是根据专家意见或病例报告/系列来指导。需要进一步研究以确立最佳治疗方案。本综述重点关注神经重症监护医生对寨卡病毒感染患者的护理——预计该病毒在夏季会再次爆发。

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