Isaacson C, Milne F J, van Niekerk I
School of Pathology, Department of Anatomical Pathology, South African Institute for Medical Research, Johannesburg.
S Afr Med J. 1989 Oct 7;76(7):323-4.
Autopsy material was examined from cases diagnosed as malignant nephrosclerosis in the years 1956-1961, a period when adequate antihypertensive therapy had not yet become available, a second group of malignant nephrosclerosis from the years 1970-1980, an era during which effective antihypertensive therapy was available, and a third group of essential benign nephrosclerosis, once more from the early pretreatment period (1956-1961). The observations suggest that malignant and benign hypertension may be two different diseases. Further studies will be pursued to assess whether hypertensive renal changes seen in this study are a spectrum of one disease extending from malignant nephrosclerosis de novo presenting with acute renal failure or chronic renal failure to benign hypertensive nephrosclerosis.
对1956年至1961年期间诊断为恶性肾硬化症的病例的尸检材料进行了检查，这一时期尚无足够的抗高血压治疗方法；第二组是1970年至1980年期间的恶性肾硬化症病例，这一时期已有有效的抗高血压治疗方法；第三组是原发性良性肾硬化症病例，同样来自早期治疗前阶段（1956年至1961年）。这些观察结果表明，恶性高血压和良性高血压可能是两种不同的疾病。将进一步开展研究，以评估本研究中所见的高血压性肾脏改变是否是一种疾病的连续谱，从新发急性肾衰竭或慢性肾衰竭的恶性肾硬化症延伸至良性高血压性肾硬化症。
