Xie Wei, Zhou Jun
Key Laboratory of Animal Resistance Biology of Shandong Province, Institute of Biomedical Sciences, College of Life Sciences, Shandong Normal University, Jinan, Shandong, China.
State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials of the Ministry of Education, College of Life Sciences, Nankai University, Tianjin, China.
J Cell Physiol. 2017 Jul;232(7):1634-1639. doi: 10.1002/jcp.25750. Epub 2017 Feb 21.
The epidermis is a stratified epithelium that serves as a barrier to infection from environmental pathogens and prevents water loss. Epidermal stratification is tightly controlled during embryogenesis. Progenitor cells in the developing epidermis undergo both symmetric and asymmetric cell divisions to balance the growth of the skin surface area against the generation of differentiated cell layers. Therefore, understanding the relationship between oriented divisions of progenitor cells and the development and stratification of the epidermis is of paramount importance in the field of skin biology and pathology. We provide here an integrated view of recent studies implicating that improper orientation of the mitotic spindle contributes to disorders associated with abnormal epidermal stratification and suggesting that spindle orientation could serve as a potential therapeutic target in skin diseases.
表皮是一种复层上皮，可作为抵御环境病原体感染的屏障并防止水分流失。在胚胎发生过程中，表皮分层受到严格控制。发育中的表皮中的祖细胞进行对称和不对称细胞分裂，以平衡皮肤表面积的增长与分化细胞层的生成。因此，了解祖细胞的定向分裂与表皮发育和分层之间的关系在皮肤生物学和病理学领域至关重要。我们在此提供了近期研究的综合观点，这些研究表明有丝分裂纺锤体的方向不当会导致与表皮异常分层相关的疾病，并表明纺锤体方向可作为皮肤病的潜在治疗靶点。
