钯催化的不对称烯丙基烷基化方法合成α-季碳 γ-丁内酯。
A Palladium-Catalyzed Asymmetric Allylic Alkylation Approach to α-Quaternary γ-Butyrolactones.
机构信息
Laboratoire de Chimie Organique, Institute of Chemistry, Biology and Innovation (CBI) - ESPCI Paris/CNRS (UMR8231), PSL Research University , 10 rue Vauquelin, 75231 Paris Cedex 05, France.
出版信息
Org Lett. 2017 Jan 6;19(1):14-17. doi: 10.1021/acs.orglett.6b02971. Epub 2016 Dec 20.
PMID:27997201
Abstract
The Pd-catalyzed asymmetric allylic alkylation (Pd-AAA) of enol carbonates derived from γ-butyrolactones is reported, affording the corresponding enantioenriched α,α'-disubstituted γ-butyrolactones in both high yields and high enantioselectivities (up to 94% ee). This method was eventually applied to the synthesis of chiral spirocyclic compounds.
摘要
报道了钯催化的γ-丁内酯衍生的烯醇碳酸酯的不对称烯丙基烷基化（Pd-AAA）反应，以高产率和高对映选择性（高达 94%ee）得到相应的对映体富集的α,α'-二取代γ-丁内酯。该方法最终被应用于手性螺环化合物的合成。
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