对在中国长春百克生物科技股份公司制备的一种候选减毒活流感疫苗在雪貂体内的安全性和有效性进行评估。
Evaluation of a candidate live attenuated influenza vaccine prepared in Changchun BCHT (China) for safety and efficacy in ferrets.
作者信息
Shen Zhenwei, Bowen Richard A, Ge Peng, Yu Jinfei, Shen Yanjie, Kong Wei, Jiang Chunlai, Wu Jinchang, Zhu Changlin, Xu Yanjun, Wei Wei, Rudenko Larisa, Kiseleva Irina, Xu Fei
机构信息
Changchun BCHT Biotechnology Co., Changchun, PR China.
Department of Biomedical Sciences, Colorado State University, Fort Collins, United States.
出版信息
Vaccine. 2016 Nov 21;34(48):5953-5958. doi: 10.1016/j.vaccine.2016.09.059. Epub 2016 Oct 26.
We evaluated the safety and efficacy of a live attenuated influenza vaccine (LAIV) product in ferrets. The BCHT LAIV product was significantly less virulent than wild-type H1N1 virus, when evaluated by comparing virus shedding and histopathologic lesions. The data indicated strong evidence for an attenuated phenotype of LAIV. Furthermore, the vaccine induced robust humoral immune responses in seronegative ferrets, and protected ferrets against development of fever, weight loss and turbinate inflammatory lesions after challenging with H3N2 wide-type influenza virus. Thus, the BCHT LAIV product was safe in healthy seronegative ferrets and protected ferrets against infection of H3N2 influenza virus.
我们评估了一种减毒活流感疫苗（LAIV）产品在雪貂中的安全性和有效性。通过比较病毒脱落和组织病理学损伤来评估时，BCHT LAIV产品的毒性明显低于野生型H1N1病毒。数据表明有强有力的证据支持LAIV的减毒表型。此外，该疫苗在血清阴性雪貂中诱导了强烈的体液免疫反应，并在雪貂受到H3N2野生型流感病毒攻击后，保护雪貂不出现发热、体重减轻和鼻甲炎性损伤。因此，BCHT LAIV产品在健康的血清阴性雪貂中是安全的，并能保护雪貂免受H3N2流感病毒的感染。
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