Wüthrich B
Ther Umsch. 1989 Sep;46(9):641-4.
The urticaria is a common skin disease, characterized by evanescent, pruritic, erythematous and oedematous wheals and sometimes by giant hives (angio-edema). Its pathogenesis is related to the activation of tissue mast cells by many immunologic or non-immunologic mechanisms, resulting in a release of biologically active products. The cause of chronic urticaria remains unknown in 75 to 80% of the cases. This form is rare in childhood. More of 50% of children with acute urticaria are atopic with preexisting dermatitis of pollinosis. A papular urticaria (prurigo strophulus), an urticaria pigmentosa, and, in case of angioedema, the hereditary form due to functional inactivity of the C1-inhibitor must be excluded. The therapeutic possibilities in the praxis are briefly discussed.
荨麻疹是一种常见的皮肤病，其特征为短暂性、瘙痒性、红斑性及水肿性风团，有时还伴有巨大荨麻疹（血管性水肿）。其发病机制与多种免疫或非免疫机制激活组织肥大细胞有关，导致生物活性产物释放。75%至80%的慢性荨麻疹病例病因不明。这种类型在儿童期较为罕见。超过50%的急性荨麻疹患儿为特应性体质，伴有先前存在的花粉症性皮炎。必须排除丘疹性荨麻疹（小儿痒疹）、色素性荨麻疹，以及血管性水肿情况下因C1抑制剂功能缺陷导致的遗传性类型。本文简要讨论了实际应用中的治疗方法。
