偏头痛患者血小板中纤维蛋白原受体的表达——与血小板糖蛋白IIb含量及血浆胆固醇的相关性

Expression of fibrinogen receptors in platelets of migraine patients--correlation with platelet GPIIb content and plasma cholesterol.

作者信息

Walkowiak B, Kozubski W, Pawlowska Z, Prusinski A, Cierniewski C S

机构信息

Department of Biophysics, Medical School, Lódź, Poland.

出版信息

Thromb Haemost. 1989 Jun 30;61(3):419-22.

PMID:2799757

Abstract

Binding of fibrinogen to platelets washed from blood of migraine patients (n = 30) and control donors (n = 24) was compared. In addition, contents of platelet glycoprotein IIb and platelet fibrinogen were determined in both groups by radioimmunoassay. The receptor capacity for fibrinogen in platelets activated by ADP was significantly higher (p less than 0.01) in migraine patients (52,505 +/- 4,925) than in controls (33,881 +/- 3,965). The mean contents of GPIIb (3.51 +/- 0.34 micrograms/10(8) platelets) and fibrinogen (37.26 +/- 4.05 micrograms/10(8) platelets) in migraine platelets were also markedly increased (p less than 0.01 and p less than 0.001, respectively) when compared to controls (2.21 +/- 0.18 micrograms of GPIIb and 18.75 +/- 2.29 micrograms of fibrinogen per 10(8) platelets, respectively). There was a high correlation between the number of fibrinogen receptors exposed by ADP and the total amount of platelet GPIIb both in migraine patients (R = 0.69, p less than 0.01) and controls (R = 0.62 p less than 0.01), as well as plasma cholesterol in the case of migraine patients (R = 0.82, p less than 0.001).

摘要

比较了从偏头痛患者（n = 30）和对照供血者（n = 24）血液中洗出的血小板与纤维蛋白原的结合情况。此外，通过放射免疫测定法测定了两组中血小板糖蛋白IIb和血小板纤维蛋白原的含量。由ADP激活的血小板中纤维蛋白原的受体容量在偏头痛患者（52,505±4,925）中显著高于对照组（33,881±3,965）（p<0.01）。与对照组相比，偏头痛患者血小板中GPIIb的平均含量（3.51±0.34微克/10⁸个血小板）和纤维蛋白原的平均含量（37.26±4.05微克/10⁸个血小板）也显著增加（分别为p<0.01和p<0.001），对照组中每10⁸个血小板中GPIIb为2.21±0.18微克，纤维蛋白原为18.75±2.29微克。在偏头痛患者（R = 0.69，p<0.01）和对照组（R = 0.62，p<0.01）中，由ADP暴露的纤维蛋白原受体数量与血小板GPIIb总量之间存在高度相关性，在偏头痛患者中还与血浆胆固醇存在高度相关性（R = 0.82，p<0.001）。