Department of Gastroenterology and Hepatology, St. Antonius Hospital, Nieuwegein, The Netherlands.
Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands.
Endoscopy. 2017 Feb;49(2):169-175. doi: 10.1055/s-0042-120117. Epub 2016 Dec 20.
Cryoablation can be used for the treatment of Barrett's esophagus (BE). A recent dosimetry study, using the CryoBalloon Focal Ablation System (CryoBalloon), demonstrated that 10-second ablations result in complete eradication of BE. However, the efficacy of 10-second ablation in a larger cohort of patients has not been investigated, nor has the potential of precise targeting of specific areas. The aim of the study was to assess the efficacy and performance (i. e. targeting of BE islands) of a 10-second cryoablation using the CryoBalloon. A total of 30 patients were enrolled (worst pathology: low grade dysplasia in 14 [47 %], high grade dysplasia in 7 [23 %], early adenocarcinoma in 9 [30 %]). Of the 47 BE islands, 44 (94 %) were adequately targeted. Complete eradication of intestinal metaplasia and dysplasia was observed in 100 % of the completely ablated areas. No stenoses were observed. Cryoablation of BE islands using the CryoBalloon is effective. BE islands were effectively targeted.
冷冻消融可用于 Barrett 食管 (BE) 的治疗。最近的一项剂量学研究使用 CryoBalloon 聚焦消融系统 (CryoBalloon) 表明，10 秒消融可彻底根除 BE。然而，尚未研究更大患者队列中 10 秒消融的疗效，也未研究精确靶向特定区域的潜力。该研究的目的是评估使用 CryoBalloon 进行 10 秒冷冻消融的疗效和性能（即 BE 岛的靶向性）。共有 30 名患者入组（最差病理：低级别异型增生 14 例 [47%]，高级别异型增生 7 例 [23%]，早期腺癌 9 例 [30%]）。在 47 个 BE 岛中，44 个（94%）得到了充分的靶向治疗。完全消融区域 100%观察到肠化生和异型增生完全根除。未观察到狭窄。使用 CryoBalloon 对 BE 岛进行冷冻消融是有效的。BE 岛得到了有效靶向。
