Department of Gastroenterology and Endoscopy, National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa, 277-8577, Japan.
Course of Advanced Clinical Research of Cancer, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo, Japan.
BMC Gastroenterol. 2021 May 22;21(1):234. doi: 10.1186/s12876-021-01819-0.
The Cryoballoon focal ablation system (CbFAS) for dysplastic Barrett's esophagus is simple, time-saving and has high therapeutic efficacy. This study aimed to evaluate the technical feasibility and tissue damage with combination therapy of endoscopic resection (ER) and CbFAS in porcine models.
Three pigs (A, B, and C) were included, and all ER procedures were performed by endoscopic mucosal resection using the Cap method (EMR). Combination therapy for each pig was performed as follows: (a) CbFAS was performed for a post-EMR mucosal defect for Pig A; (b) CbFAS for post-EMR scar for Pig B, and (c) EMR for post-CbFAS scar for Pig C. All pigs were euthanized at 32 days after the initial procedure, and the tissue damage was evaluated.
All endoscopic procedures were followed as scheduled. None of the subjects experienced anorexia, rapid weight loss, bleeding, and perforation during the observation period. They were euthanized at 32 days after the initial endoscopic procedure. On histological assessment, there was little difference between the tissue that was treated with CbFAS alone and that treated with CbFAS in combination with ER.
Combination therapy with ER and CbFAS can be technically feasible, and its outcome was not significantly different from CbFAS alone in terms of tissue damage.
冷冻球囊聚焦消融系统（CbFAS）治疗发育异常性 Barrett 食管简单、省时，且疗效高。本研究旨在评估内镜下黏膜切除术（EMR）联合 CbFAS 在猪模型中的技术可行性和组织损伤。
纳入 3 头猪（A、B 和 C），所有 EMR 操作均采用 Cap 法进行。每头猪的联合治疗如下：（a）对 A 猪的 EMR 后黏膜缺损行 CbFAS；（b）对 B 猪的 EMR 后瘢痕行 CbFAS；（c）对 C 猪的 CbFAS 后瘢痕行 EMR。所有猪在初次内镜操作后 32 天处死，评估组织损伤。
所有内镜操作均按计划进行。观察期间，所有动物均未出现厌食、体重迅速下降、出血和穿孔。它们在初次内镜操作后 32 天被处死。组织学评估显示，单独使用 CbFAS 与 CbFAS 联合 EMR 治疗的组织之间差异很小。
ER 联合 CbFAS 的联合治疗在技术上是可行的，在组织损伤方面与单独使用 CbFAS 没有显著差异。
