Wang G, Cao L Y, Chen S H, Xie S H, Feng X S, Lyu Z Y, Guo L W, Li F, Su K, Chang S, Ren J S, Dai M, Li N, Wu S L, He J
Department of Oncology, Kailuan General Hospital, Tangshan 063000, China.
Department of Hepatobiliary Surgery, Kailuan General Hospital, Tangshan 063000, China.
Zhonghua Zhong Liu Za Zhi. 2016 Nov 23;38(11):876-880. doi: 10.3760/cma.j.issn.0253-3766.2016.11.015.
It has been reported by some prospective studies that C-reactive protein (CRP) is associated with cancer risk. However, the correlation between CRP and digestive system cancers has not been evaluated in Chinese females. We conducted a large population-based cohort study to investigate whether elevated level of CRP in serum is associated with an increased risk of digestive system cancers in Chinese women. From the Chinese Kailuan Female Cohort, 19, 437 women were enrolled in this study in July 2006, and all of the subjects were followed up through 2014. At the baseline investigation, the serum levels of high-sensitivity CRP (hsCRP) were tested for all subjects, and demographic information and risk factor data were collected. Multivariable Cox proportional hazards regression model was used to calculate the hazard ratios () and 95% confidence intervals (95% ) for the baseline levels of hsCRP after adjusting for age, marital status, smoking, drinking, body mass index (BMI), diabetes and physical activity, and risk of digestive system tumors (including colorectal cancer, stomach cancer, pancreas cancer, liver and gallbladder cancer, and other cancers). By Dec 31, 2014, a total of 100 incident cancer cases were observed, including 47 colorectal cancers, 17 stomach cancers, and altogether 29 pancreas, liver and gallbladder cancers. All the subjects investigated were divided into three groups according to the level of hsCRP (<1 mg/L, 1-3 mg/L and >3 mg/L). The 8-year cumulative incidence of digestive system cancers were 405/100 000, 520/100 000 and 787/100 000 in these 3 groups, respectively (Log rank test = 8.37, =0.015). Compared to those with lower hsCRP levels (<1 mg/L), the women with higher hsCRP (>3 mg/L) had a significantly increased risk of pancreas, liver and gallbladder cancers ( = 2.70, 95% = 1.06-6.91; = 0.036). Elevated levels of hsCRP at baseline may be associated with increased risk of certain digestive system cancers.
一些前瞻性研究报告称，C反应蛋白（CRP）与癌症风险相关。然而，在中国女性中，CRP与消化系统癌症之间的相关性尚未得到评估。我们开展了一项基于大规模人群的队列研究，以调查血清中CRP水平升高是否与中国女性消化系统癌症风险增加有关。2006年7月，从中国开滦女性队列中纳入了19437名女性，所有受试者均随访至2014年。在基线调查时，对所有受试者检测了高敏CRP（hsCRP）的血清水平，并收集了人口统计学信息和风险因素数据。采用多变量Cox比例风险回归模型，在调整年龄、婚姻状况、吸烟、饮酒、体重指数（BMI）、糖尿病和身体活动以及消化系统肿瘤风险（包括结直肠癌、胃癌、胰腺癌、肝癌和胆囊癌以及其他癌症）后，计算hsCRP基线水平的风险比（HR）和95%置信区间（95%CI）。到2014年12月31日，共观察到100例新发癌症病例，包括47例结直肠癌、17例胃癌以及总共29例胰腺癌、肝癌和胆囊癌。根据hsCRP水平（<1mg/L、1 - 3mg/L和>3mg/L）将所有调查对象分为三组。这三组中消化系统癌症的8年累积发病率分别为405/100000、520/100000和787/100000（对数秩检验χ² = 8.37，P = 0.015）。与hsCRP水平较低（<1mg/L）的女性相比，hsCRP水平较高（>3mg/L）的女性患胰腺癌、肝癌和胆囊癌的风险显著增加（HR = 2.70，95%CI = 1.06 - 6.91；P = 0.036）。基线时hsCRP水平升高可能与某些消化系统癌症风险增加有关。
