Centre de Physiopathologie de Toulouse Purpan, INSERM U1043/CNRS UMR5282/Université Toulouse III Paul-Sabatier, F-31024, Toulouse, France; CHU Toulouse, Hôpital Purpan, Laboratoire de virologie, Centre National de Référence Hépatite E, Institut Fédératif de Biologie, F-31300, Toulouse, France.
Centre de Physiopathologie de Toulouse Purpan, INSERM U1043/CNRS UMR5282/Université Toulouse III Paul-Sabatier, F-31024, Toulouse, France; CHU Toulouse, Hôpital Purpan, Laboratoire de virologie, Centre National de Référence Hépatite E, Institut Fédératif de Biologie, F-31300, Toulouse, France.
J Infect. 2017 Mar;74(3):310-313. doi: 10.1016/j.jinf.2016.12.004. Epub 2016 Dec 18.
The reported prevalence of anti-hepatitis E virus antibodies in HIV-positive patients from industrialized countries varies greatly. It is also difficult to compare these data with the anti-IgG prevalence in the general population because age and sex are not matched in most studies. Moreover, MSM are at increased risk of viral hepatitis.
HEV is endemic in southwestern France. We investigated therefore 300 HIV-infected patients consecutively attending the out-patient clinic of Toulouse University Hospital. Each HIV-infected patient was matched for sex and age with 2 healthy blood donors from the same area. They were tested for anti-HEV IgM and IgG.
Anti-HEV IgG was found in 116 HIV-infected patients (38.7%) and in 284 matched controls (47.3%, p = 0.027). However, anti-HEV IgG concentration tended to be lower in HIV-patients than in controls. Anti-HEV IgM prevalence was similar HIV-infected patients (3.6%) and in matched controls (3.8%, p = 0.85).
The prevalence and concentrations of anti-HEV IgG in HIV-infected patients from Southern-France were lower than in controls, suggesting a weaker humoral response. But their prevalences of anti-HEV IgM were similar, indicating a high incidence of HEV infection. These data do not indicate that HEV is transmitted sexually.
工业化国家 HIV 阳性患者抗戊型肝炎病毒（HEV）抗体的报告流行率差异很大。由于大多数研究未匹配年龄和性别，因此难以将这些数据与一般人群中的抗 IgG 流行率进行比较。此外，男男性行为者（MSM）感染病毒性肝炎的风险增加。
HEV 在法国西南部流行。因此，我们连续调查了图卢兹大学医院门诊的 300 名 HIV 感染患者。每位 HIV 感染患者均与来自同一地区的 2 名健康献血者按性别和年龄匹配。他们接受了抗 HEV IgM 和 IgG 检测。
在 116 名 HIV 感染患者（38.7%）和 284 名匹配对照者（47.3%，p=0.027）中发现了抗 HEV IgG。但是，HIV 患者的抗 HEV IgG 浓度往往低于对照者。HIV 感染患者和匹配对照者的抗 HEV IgM 流行率相似（3.6%和 3.8%，p=0.85）。
法国南部 HIV 感染患者的抗 HEV IgG 流行率和浓度低于对照者，提示体液免疫反应较弱。但是，他们的抗 HEV IgM 流行率相似，表明 HEV 感染发生率较高。这些数据并不表明 HEV 通过性传播。
