Chew M Y, Ng J, Cai H-M, Lim T G, Lim T K
Division of Respiratory and Critical Care Medicine, University Medicine Cluster, National University Hospital, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore.
Department of Rehabilitation, National University Hospital, Singapore.
Int J Tuberc Lung Dis. 2016 Dec 1;20(12):1668-1670. doi: 10.5588/ijtld.16.0123.
We performed a prospective clinical audit in hospitalised patients with suspected pulmonary tuberculosis (PTB) with the objective of evaluating the accuracy and clinical utility of Xpert® MTB/RIF in induced sputum in an intermediate-burden setting. Of 450 patients audited, 61 (13.6%) were diagnosed with PTB based on positive culture. The sensitivity, specificity and positive and negative predictive values for Xpert in smear-negative cases for induced sputum were respectively 75%, 99.5%, 94.7% and 97.0%. Xpert in induced sputum may facilitate diagnostic yield and expedite treatment in up to a quarter of PTB patients.
我们对疑似肺结核（PTB）的住院患者进行了一项前瞻性临床审计，目的是评估在中等负担环境下，Xpert® MTB/RIF检测诱导痰对肺结核的诊断准确性和临床实用性。在接受审计的450例患者中，61例（13.6%）基于培养阳性被诊断为PTB。诱导痰涂片阴性病例中，Xpert检测的敏感度、特异度、阳性预测值和阴性预测值分别为75%、99.5%、94.7%和97.0%。诱导痰Xpert检测可能有助于提高多达四分之一的PTB患者的诊断率并加快治疗。
