Eras Mederos A, Acosta Dominguez A, García Proveyer A, Ramos Alvarez F, Perez Oliva J
Urol Nefrol (Mosk). 1989 Jul-Aug(4):10-1.
A total of 14 patients with acute rejection of transplanted kidney were treated with plasmapheresis (in combination with prednisolone supporting therapy in a dose of 15 mg/kg). For the arrest of the rejection it was necessary to use 4 sessions of plasmapheresis on average for each person (from 3 to 8 sessions). The average volume of discharged plasma, 2,000 ml approximately, was compensated with frozen plasma. Plasmapheresis was exercised by plasma separation with an "Asahi" plasma filter with the surface of 0.5 m2. Plasmapheresis successfully arrested the rejection in 50 per cent of the patients. Pathogenetic reasonability of plasmapheresis for the treatment of the aforementioned patients (elimination of toxins, circulating immune complexes, elevation of C3 and C4 components of the complement) was substantiated. In patients who had undergone plasmapheresis for the arrest of acute rejection, lowered levels of proteinuria were considered as a favourable prognostic sign.
共有14例移植肾急性排斥反应患者接受了血浆置换治疗（联合使用剂量为15mg/kg的泼尼松龙支持疗法）。为阻止排斥反应，平均每人需要进行4次血浆置换（3至8次）。排出的血浆平均量约为2000ml，用冰冻血浆进行补充。使用表面积为0.5平方米的“旭化成”血浆滤器通过血浆分离进行血浆置换。血浆置换成功阻止了50%患者的排斥反应。证实了血浆置换治疗上述患者的发病机制合理性（清除毒素、循环免疫复合物、提高补体C3和C4成分）。在接受血浆置换以阻止急性排斥反应的患者中，蛋白尿水平降低被视为良好的预后标志。
