Janušonis Skirmantas
Department of Psychological and Brain Sciences, University of California , Santa Barbara, California 93106-9660, United States.
ACS Chem Neurosci. 2017 May 17;8(5):893-896. doi: 10.1021/acschemneuro.6b00417. Epub 2016 Dec 21.
All brain regions contain fibers that store and release 5-hydroxytryptamine (5-HT, serotonin). Since these fibers often do not have well-defined trajectories, most studies have focused on their overall densities, a measure that can be associated with local 5-HT tone in heathy and diseased brains. However, the observed fiber densities are the consequence of the behavior of single fibers. Evidence is presented as to why understanding single-fiber trajectories is important for basic and clinical neuroscience. In particular, serotonergic fibers can be viewed as natural, readily detectable stochastic probes that sample the invisible microarchitecture of brain tissue.
所有脑区都含有储存和释放5-羟色胺（5-HT，血清素）的纤维。由于这些纤维的轨迹通常不明确，大多数研究都集中在它们的总体密度上，这一指标可与健康和患病大脑中的局部5-HT水平相关。然而，观察到的纤维密度是单根纤维行为的结果。本文提供了证据，说明理解单根纤维轨迹对基础和临床神经科学为何重要。特别是，血清素能纤维可被视为对脑组织不可见微结构进行采样的天然、易于检测的随机探针。
