Department of Chemistry and Biochemistry, ‡Department of Nanoengineering, §Department of Computer, ∥Department of Surgery, ⊥Department of Radiology, and #Materials Science and Engineering Program, University of California, San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States.
ACS Appl Mater Interfaces. 2017 Jan 18;9(2):1719-1727. doi: 10.1021/acsami.6b10728. Epub 2017 Jan 5.
Ultrasound imaging is a safe, low-cost, and in situ method for detecting in vivo medical devices. A poly(methyl-2-cyanoacrylate) film containing 2 μm boron-doped, calcined, porous silica microshells was developed as an ultrasound imaging marker for multiple medical devices. A macrophase separation drove the gas-filled porous silica microshells to the top surface of the polymer film by controlled curing of the cyanoacrylate glue and the amount of microshell loading. A thin film of polymer blocked the wall pores of the microshells to seal air in their hollow core, which served as an ultrasound contrast agent. The ultrasound activity disappeared when curing conditions were modified to prevent the macrophase segregation. Phase segregated films were attached to multiple surgical tools and needles and gave strong color Doppler signals in vitro and in vivo with the use of a clinical ultrasound imaging instrument. Postprocessing of the simultaneous color Doppler and B-mode images can be used for autonomous identification of implanted surgical items by correlating the two images. The thin films were also hydrophobic, thereby extending the lifetime of ultrasound signals to hours of imaging in tissues by preventing liquid penetration. This technology can be used as a coating to guide the placement of implantable medical devices or used to image and help remove retained surgical items.
超声成像是一种安全、低成本、原位的方法，用于检测体内医疗设备。开发了一种含有 2μm 硼掺杂、煅烧、多孔硅微球的聚甲基-2-氰基丙烯酸酯膜，作为多种医疗设备的超声成像标记物。通过控制氰基丙烯酸酯胶的固化和微球的加载量，大相分离将充气体多孔硅微球驱动到聚合物膜的顶部表面。聚合物的薄膜阻止了微球的壁孔，将空气密封在其空心核心内，用作超声对比剂。当固化条件被修改以防止大相分离时，超声活性就会消失。相分离的薄膜被附着在多个手术工具和针上，并在使用临床超声成像仪器时在体外和体内产生强烈的彩色多普勒信号。通过对两种图像进行相关处理，可以对植入的手术物品进行自动识别。这种薄膜还具有疏水性，通过防止液体渗透，将超声信号的寿命延长至数小时的组织成像。该技术可用作涂层，以指导可植入医疗设备的放置，或用于成像和帮助去除遗留的手术物品。
