Yang Jian, Ward Erin, Sung Tsai W, Wang James, Barback Christopher, Mendez Natalie, Blair Sarah, Trogler William C, Kummel Andrew C
Department of Surgery, University of California, San Diego, 200 West Arbor Drive, San Diego, California 92103, United States.
Department of Radiology, University of California, San Diego, 410 Dickinson Street, San Diego, California 92103, United States.
ACS Biomater Sci Eng. 2017 Aug 14;3(8):1780-1787. doi: 10.1021/acsbiomaterials.7b00223. Epub 2017 Jun 21.
Ultrasound (US) guided medical devices placement is a widely used clinical technology, yet many factors affect the visualization of these devices in the human body. In this research, an ultrasound-activated film was developed that can be coated on the surface of medical devices. The film contains 2 μm silica microshells and poly(methyl 2-cyanoacrylate) (PMCA) adhesive. The air sealed in the hollow space of the microshells acted as the US contrast agent. Ozone and perfluorooctyltriethoxysilane (PFO) were used to treat the surface of the film to enhance the US signals and provide durable antifouling properties for multiple passes through tissue, consistent with the dual oleophobic and hydrophobic nature of PFO. In vitro and in vivo tests showed that hypodermic needles and tumor marking wires coated with US activated film gave strong and persistent color Doppler signals. This technology can significantly improve the visibility of medical devices and the accuracy of US guided medical device placement.
超声（US）引导下的医疗设备放置是一种广泛应用的临床技术，但许多因素会影响这些设备在人体中的可视化。在本研究中，开发了一种可涂覆在医疗设备表面的超声激活薄膜。该薄膜包含2μm的二氧化硅微壳和聚（2-氰基丙烯酸甲酯）（PMCA）粘合剂。密封在微壳中空空间中的空气充当超声造影剂。使用臭氧和全氟辛基三乙氧基硅烷（PFO）处理薄膜表面，以增强超声信号，并为多次穿过组织提供持久的防污性能，这与PFO的双疏油性和疏水性一致。体外和体内测试表明，涂有超声激活薄膜的皮下注射针和肿瘤标记线给出了强烈且持久的彩色多普勒信号。该技术可显著提高医疗设备的可视性以及超声引导下医疗设备放置的准确性。
