Jiang Min-Shan, Zhu Jing-Yuan, Li Xue, Zhang Nan-Nan, Zhang Xue-Dian
*Engineering Research Center of Optical Instruments and Systems, Ministry of Education, Shanghai Key Lab of Modern Optical Systems, University of Shanghai for Science and Technology, Shanghai, China; and †Department of Biomedical Engineering, Florida International University, Miami, FL.
Cornea. 2017 Mar;36(3):310-316. doi: 10.1097/ICO.0000000000001113.
To evaluate the corneal biomechanical properties of patients who have undergone penetrating keratoplasty (PK) or deep anterior lamellar keratoplasty (DALK) using the ocular response analyzer.
Stata 13.0 SE was used for this meta-analysis. Studies in the literature that focused on corneal hysteresis (CH) or corneal resistance factor (CRF) after PK or DALK were retrieved by searching PubMed, Embase, Ovid, and Cochrane databases. We present the results as weighted mean difference (WMD) with a corresponding 95% confidence interval (CI).
Eight studies with a total of 750 eyes were included in the post-PK versus control group, and 4 studies with a total of 218 eyes were included in the post-DALK versus control group. The pooled results showed that CH and CRF were significantly reduced (P < 0.00001) for patients who have undergone PK (WMD = -1.16, 95% CI: -1.73 to -0.60 and WMD = -1.00, 95% CI: -1.61 to -0.40). No significant differences were found in both CH and CRF for patients who have undergone DALK (WMD = -0.27, 95% CI: -0.64 to -0.09 and WMD = -0.15, 95% CI: -0.53 to 0.23).
This meta-analysis suggested that both CH and CRF had better recovery after corneal transplantation with DALK than PK.
使用眼反应分析仪评估接受穿透性角膜移植术（PK）或深板层角膜移植术（DALK）患者的角膜生物力学特性。
本荟萃分析使用Stata 13.0 SE。通过检索PubMed、Embase、Ovid和Cochrane数据库，获取文献中聚焦于PK或DALK术后角膜滞后（CH）或角膜阻力因子（CRF）的研究。我们将结果表示为加权平均差（WMD）及相应的95%置信区间（CI）。
PK术后与对照组相比的研究纳入了8项，共750只眼；DALK术后与对照组相比的研究纳入了4项，共218只眼。汇总结果显示，接受PK手术的患者CH和CRF显著降低（P < 0.00001）（WMD = -1.16，95% CI：-1.73至-0.60；WMD = -1.00，95% CI：-1.61至-0.40）。接受DALK手术的患者CH和CRF均未发现显著差异（WMD = -0.27，95% CI：-0.64至-0.09；WMD = -0.15，95% CI：-0.53至0.23）。
本荟萃分析表明，与PK相比，DALK角膜移植术后CH和CRF的恢复情况更好。
