• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Sprouty2通过抑制FGFR2诱导的ERK磷酸化和癌症进展与胃腺癌的良好预后相关。

Sprouty2 correlates with favorable prognosis of gastric adenocarcinoma via suppressing FGFR2-induced ERK phosphorylation and cancer progression.

作者信息

Xu Yunfei, Yang Xiaoqing, Li Zhen, Li Shuo, Guo Sen, Ismail Sayed, Liu Hongda, Huang Zhihong, Zhang Zongli, Chen Yuxin, Sun Qing

机构信息

Department of General Surgery, Qilu Hospital Affiliated to Shandong University, Jinan, Shandong, China.

Department of Pathology, Qianfoshan Hospital Affiliated to Shandong University, Jinan, Shandong, China.

出版信息

Oncotarget. 2017 Jan 17;8(3):4888-4900. doi: 10.18632/oncotarget.13982.

DOI:10.18632/oncotarget.13982
PMID:28002800
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5354878/
Abstract

Fibroblast growth factor receptor 2 (FGFR2) has been identified as a predictive biomarker for unfavorable prognosis of gastric adenocarcinoma. As a well-defined antagonist in FGFR2-induced RAS/ERK activation, ectopic expression of sprouty (SPRY) family was reported in several kinds of cancers except gastric cancer. To explore the clinical significance of SPRY family and its correlation with FGFR2, we detected the expression of FGFR2 and SPRY family in 104 cases of gastric adenocarcinoma and subsequently analyzed their correlations with clinicopathological factors and overall survival rates by univariate and multivariate analysis. As the result, we demonstrated that both FGFR2 high-expression and SPRY2 low-expression indicated poorer prognosis of gastric adenocarcinoma. SPRY2 low-expression was significantly associated with FGFR2 high-expression, positive lymphatic invasion and metastasis. We further proved that SPRY2 could suppress FGFR2-induced ERK phosphorylation, cell proliferation and invasion with experiments in vitro and in vivo. In conclusion, we demonstrated that SPRY2 low-expression is a biomarker for unfavorable prognosis in gastric adenocarcinoma. SPRY2 can antagonize FGFR2-induced proliferation and invasion via suppressing ERK phosphorylation in gastric cancer cells, indicating SPRY2 as a potential therapeutic target for gastric adenocarcinoma treatment.

摘要

成纤维细胞生长因子受体2（FGFR2）已被确定为胃腺癌预后不良的预测生物标志物。作为FGFR2诱导的RAS/ERK激活中一种明确的拮抗剂，除胃癌外，在几种癌症中均报道了Sprouty（SPRY）家族的异位表达。为了探讨SPRY家族的临床意义及其与FGFR2的相关性，我们检测了104例胃腺癌中FGFR2和SPRY家族的表达，并随后通过单因素和多因素分析分析了它们与临床病理因素和总生存率的相关性。结果表明，FGFR2高表达和SPRY2低表达均提示胃腺癌预后较差。SPRY2低表达与FGFR2高表达、阳性淋巴浸润和转移显著相关。我们通过体内外实验进一步证明，SPRY2可抑制FGFR2诱导的ERK磷酸化、细胞增殖和侵袭。总之，我们证明SPRY2低表达是胃腺癌预后不良的生物标志物。SPRY2可通过抑制胃癌细胞中的ERK磷酸化来拮抗FGFR2诱导的增殖和侵袭，表明SPRY2是胃腺癌治疗的潜在治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fedc/5354878/4a84fe8be809/oncotarget-08-4888-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fedc/5354878/701de11fb23c/oncotarget-08-4888-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fedc/5354878/e81108a760cd/oncotarget-08-4888-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fedc/5354878/55a5404536f8/oncotarget-08-4888-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fedc/5354878/4a84fe8be809/oncotarget-08-4888-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fedc/5354878/701de11fb23c/oncotarget-08-4888-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fedc/5354878/e81108a760cd/oncotarget-08-4888-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fedc/5354878/55a5404536f8/oncotarget-08-4888-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fedc/5354878/4a84fe8be809/oncotarget-08-4888-g005.jpg

相似文献

1
Sprouty2 correlates with favorable prognosis of gastric adenocarcinoma via suppressing FGFR2-induced ERK phosphorylation and cancer progression.Sprouty2通过抑制FGFR2诱导的ERK磷酸化和癌症进展与胃腺癌的良好预后相关。
Oncotarget. 2017 Jan 17;8(3):4888-4900. doi: 10.18632/oncotarget.13982.
2
Sprouty2 suppresses progression and correlates to favourable prognosis of intrahepatic cholangiocarcinoma via antagonizing FGFR2 signalling.Sprouty2 通过拮抗 FGFR2 信号抑制肝内胆管癌的进展并与良好的预后相关。
J Cell Mol Med. 2018 Nov;22(11):5596-5606. doi: 10.1111/jcmm.13833. Epub 2018 Aug 30.
3
Twist1 correlates with poor differentiation and progression in gastric adenocarcinoma via elevation of FGFR2 expression.Twist1通过提高FGFR2表达水平与胃腺癌的低分化和进展相关。
World J Gastroenterol. 2014 Dec 28;20(48):18306-15. doi: 10.3748/wjg.v20.i48.18306.
4
Sprouty4 correlates with favorable prognosis in perihilar cholangiocarcinoma by blocking the FGFR-ERK signaling pathway and arresting the cell cycle.Sprouty4 通过阻断 FGFR-ERK 信号通路和阻止细胞周期来与肝门部胆管癌的良好预后相关。
EBioMedicine. 2019 Dec;50:166-177. doi: 10.1016/j.ebiom.2019.11.021. Epub 2019 Nov 22.
5
Upregulation of microRNA‑27b contributes to the migration and invasion of gastric cancer cells via the inhibition of sprouty2‑mediated ERK signaling.微小RNA-27b的上调通过抑制Sprouty2介导的ERK信号传导促进胃癌细胞的迁移和侵袭。
Mol Med Rep. 2016 Mar;13(3):2267-72. doi: 10.3892/mmr.2016.4779. Epub 2016 Jan 13.
6
Sprouty2 inhibits amphiregulin-induced down-regulation of E-cadherin and cell invasion in human ovarian cancer cells.Sprouty2抑制双调蛋白诱导的人卵巢癌细胞中E-钙黏蛋白的下调和细胞侵袭。
Oncotarget. 2016 Dec 6;7(49):81645-81660. doi: 10.18632/oncotarget.13162.
7
Fibroblast growth factor receptor 2 expression, but not its genetic amplification, is associated with tumor growth and worse survival in esophagogastric junction adenocarcinoma.成纤维细胞生长因子受体2的表达而非其基因扩增，与食管胃交界腺癌的肿瘤生长及较差的生存率相关。
Oncotarget. 2016 Apr 12;7(15):19748-61. doi: 10.18632/oncotarget.7782.
8
Sprouty 2 protein, but not Sprouty 4, is an independent prognostic biomarker for human epithelial ovarian cancer.Sprouty 2 蛋白而非 Sprouty 4 蛋白是人类上皮性卵巢癌的独立预后生物标志物。
Int J Cancer. 2015 Aug 1;137(3):560-70. doi: 10.1002/ijc.29425. Epub 2015 Jan 29.
9
Down-regulation of Sprouty2 in non-small cell lung cancer contributes to tumor malignancy via extracellular signal-regulated kinase pathway-dependent and -independent mechanisms.Sprouty2在非小细胞肺癌中的下调通过细胞外信号调节激酶途径依赖性和非依赖性机制促进肿瘤恶性进展。
Mol Cancer Res. 2007 May;5(5):509-20. doi: 10.1158/1541-7786.MCR-06-0273.
10
MiR-592 Promotes Gastric Cancer Proliferation, Migration, and Invasion Through the PI3K/AKT and MAPK/ERK Signaling Pathways by Targeting Spry2.微小RNA-592通过靶向Sprouty2蛋白，经由PI3K/AKT和MAPK/ERK信号通路促进胃癌的增殖、迁移和侵袭。
Cell Physiol Biochem. 2018;47(4):1465-1481. doi: 10.1159/000490839. Epub 2018 Jun 21.

引用本文的文献

1
FGF19 and FGFR4 promotes the progression of gallbladder carcinoma in an autocrine pathway dependent on GPBAR1-cAMP-EGR1 axis.成纤维细胞生长因子 19 和 FGFR4 通过依赖于 GPBAR1-cAMP-EGR1 轴的自分泌途径促进胆囊癌的进展。
Oncogene. 2021 Jul;40(30):4941-4953. doi: 10.1038/s41388-021-01850-1. Epub 2021 Jun 23.
2
NT5DC2 promotes tumor cell proliferation by stabilizing EGFR in hepatocellular carcinoma.NT5DC2 通过稳定肝癌中的 EGFR 促进肿瘤细胞增殖。
Cell Death Dis. 2020 May 7;11(5):335. doi: 10.1038/s41419-020-2549-2.
3
High Expression of RING Finger Protein 126 Predicts Unfavorable Prognosis of Epithelial Ovarian Cancer.

本文引用的文献

1
Global cancer statistics, 2012.全球癌症统计数据，2012 年。
CA Cancer J Clin. 2015 Mar;65(2):87-108. doi: 10.3322/caac.21262. Epub 2015 Feb 4.
2
Multiple receptor tyrosine kinase activation attenuates therapeutic efficacy of the fibroblast growth factor receptor 2 inhibitor AZD4547 in FGFR2 amplified gastric cancer.多种受体酪氨酸激酶激活减弱了成纤维细胞生长因子受体2抑制剂AZD4547在FGFR2扩增胃癌中的治疗效果。
Oncotarget. 2015 Feb 10;6(4):2009-22. doi: 10.18632/oncotarget.2987.
3
The developing story of Sprouty and cancer.Sprouty与癌症的发展历程
RING 指蛋白 126 高表达预示上皮性卵巢癌不良预后。
Med Sci Monit. 2020 Apr 7;26:e921370. doi: 10.12659/MSM.921370.
4
P120-Catenin And Its Phosphorylation On Tyr228 Inhibits Proliferation And Invasion In Colon Adenocarcinoma Cells.P120连环蛋白及其酪氨酸228位点的磷酸化抑制结肠腺癌细胞的增殖和侵袭。
Onco Targets Ther. 2019 Nov 26;12:10213-10225. doi: 10.2147/OTT.S211973. eCollection 2019.
5
Prognostic significance of stromal SMYD3 expression in colorectal cancer of TNM stage I-III.TNM 分期为 I - III 期的结直肠癌中基质 SMYD3 表达的预后意义
Int J Clin Exp Pathol. 2017 Aug 1;10(8):8901-8907. eCollection 2017.
6
High expression of brain-derived neurotrophic factor in intrahepatic cholangiocarcinoma is associated with intraneural invasion and unfavorable prognosis.脑源性神经营养因子在肝内胆管癌中的高表达与神经侵犯及不良预后相关。
Int J Clin Exp Pathol. 2017 Oct 1;10(10):10399-10405. eCollection 2017.
7
Sprouty4 correlates with favorable prognosis in perihilar cholangiocarcinoma by blocking the FGFR-ERK signaling pathway and arresting the cell cycle.Sprouty4 通过阻断 FGFR-ERK 信号通路和阻止细胞周期来与肝门部胆管癌的良好预后相关。
EBioMedicine. 2019 Dec;50:166-177. doi: 10.1016/j.ebiom.2019.11.021. Epub 2019 Nov 22.
8
High Expression of Serine Hydroxymethyltransferase 2 Indicates Poor Prognosis of Gastric Cancer Patients.丝氨酸羟甲基转移酶 2 高表达预示胃癌患者预后不良。
Med Sci Monit. 2019 Oct 3;25:7430-7438. doi: 10.12659/MSM.917435.
9
Annexin10 promotes extrahepatic cholangiocarcinoma metastasis by facilitating EMT via PLA2G4A/PGE2/STAT3 pathway.膜联蛋白 10 通过 PLA2G4A/PGE2/STAT3 通路促进肝外胆管癌转移 EMT。
EBioMedicine. 2019 Sep;47:142-155. doi: 10.1016/j.ebiom.2019.08.062. Epub 2019 Sep 3.
10
CDHR5 inhibits proliferation of hepatocellular carcinoma and predicts clinical prognosis.CDHR5 抑制肝癌的增殖并预测临床预后。
Ir J Med Sci. 2020 May;189(2):439-447. doi: 10.1007/s11845-019-02092-7. Epub 2019 Sep 3.
Cancer Metastasis Rev. 2014 Sep;33(2-3):695-720. doi: 10.1007/s10555-014-9497-1.
4
Casein kinase 1 regulates Sprouty2 in FGF-ERK signaling.酪蛋白激酶 1 调控 FGF-ERK 信号通路中的 Sprouty2。
Oncogene. 2015 Jan 22;34(4):474-84. doi: 10.1038/onc.2013.564. Epub 2014 Jan 27.
5
FGFR2 amplification has prognostic significance in gastric cancer: results from a large international multicentre study.FGFR2 扩增在胃癌中有预后意义：一项大型国际多中心研究的结果。
Br J Cancer. 2014 Feb 18;110(4):967-75. doi: 10.1038/bjc.2013.802. Epub 2014 Jan 23.
6
FGF receptors: cancer biology and therapeutics.成纤维细胞生长因子受体：癌症生物学与治疗学。
Med Res Rev. 2014 Mar;34(2):280-300. doi: 10.1002/med.21288. Epub 2013 May 21.
7
Cross-talk between MET and EGFR in non-small cell lung cancer involves miR-27a and Sprouty2.非小细胞肺癌中 MET 和 EGFR 之间的串扰涉及 miR-27a 和 Sprouty2。
Proc Natl Acad Sci U S A. 2013 May 21;110(21):8573-8. doi: 10.1073/pnas.1302107110. Epub 2013 May 6.
8
SPROUTY2 is a β-catenin and FOXO3a target gene indicative of poor prognosis in colon cancer.SPROUTY2 是β-连环蛋白和 FOXO3a 的靶基因，提示结直肠癌预后不良。
Oncogene. 2014 Apr 10;33(15):1975-85. doi: 10.1038/onc.2013.140. Epub 2013 Apr 29.
9
Identification of targetable FGFR gene fusions in diverse cancers.鉴定多种癌症中可靶向的 FGFR 基因融合。
Cancer Discov. 2013 Jun;3(6):636-47. doi: 10.1158/2159-8290.CD-13-0050. Epub 2013 Apr 4.
10
Sprouty2, PTEN, and PP2A interact to regulate prostate cancer progression.Sprouty2、PTEN 和 PP2A 相互作用以调节前列腺癌的进展。
J Clin Invest. 2013 Mar;123(3):1157-75. doi: 10.1172/JCI63672. Epub 2013 Feb 22.