Masoumi-Moghaddam Samar, Amini Afshin, Morris David Lawson
UNSW Department of Surgery, University of New South Wales, St George Hospital, Kogarah, Sydney, NSW, 2217, Australia,
Cancer Metastasis Rev. 2014 Sep;33(2-3):695-720. doi: 10.1007/s10555-014-9497-1.
Sprouty proteins are evolutionarily conserved modulators of MAPK/ERK pathway. Through interacting with an increasing number of effectors, mediators, and regulators with ultimate influence on multiple targets within or beyond ERK, Sprouty orchestrates a complex, multilayered regulatory system and mediates a crosstalk among different signaling pathways for a coordinated cellular response. As such, Sprouty has been implicated in various developmental and physiological processes. Evidence shows that ERK is aberrantly activated in malignant conditions. Accordingly, Sprouty deregulation has been reported in different cancer types and shown to impact cancer development, progression, and metastasis. In this article, we have tried to provide an overview of the current knowledge about the Sprouty physiology and its regulatory functions in health, as well as an updated review of the Sprouty status in cancer. Putative implications of Sprouty in cancer biology, their clinical relevance, and their proposed applications are also revisited. As a developing story, however, role of Sprouty in cancer remains to be further elucidated.
Sprouty蛋白是丝裂原活化蛋白激酶/细胞外信号调节激酶（MAPK/ERK）信号通路在进化上保守的调节因子。通过与越来越多的效应器、介质和调节因子相互作用，最终对ERK内外的多个靶点产生影响，Sprouty精心构建了一个复杂的、多层次的调节系统，并介导不同信号通路之间的串扰，以实现协调的细胞反应。因此，Sprouty参与了各种发育和生理过程。有证据表明，ERK在恶性肿瘤状态下会异常激活。相应地，不同癌症类型中均报道了Sprouty失调的情况，并且显示其会影响癌症的发生、发展和转移。在本文中，我们试图概述目前关于Sprouty生理学及其在健康中的调节功能的知识，以及对Sprouty在癌症中的现状进行更新综述。还重新审视了Sprouty在癌症生物学中的潜在意义、它们的临床相关性以及它们的潜在应用。然而，作为一个仍在发展的研究领域，Sprouty在癌症中的作用仍有待进一步阐明。
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