Shi F H, Lin B F, Qian C G, Li M, Fang M B, Ma J L, Shen W, Wang S W, Jian X L
Shanghai Institute of Animal Schistosomiasis, Chinese Academy of Agricultural Sciences.
Vet Parasitol. 1989 Sep;33(2):117-24. doi: 10.1016/0304-4017(89)90059-9.
Eighteen Chinese cattle were experimentally infected with metacercariae of Fasciola hepatica and randomly assigned to 6 groups. Five groups of cattle were treated with a single oral dose of triclabendazole at a dose rate of 12 mg kg-1. At necropsy, the reduction in fluke burden compared with the untreated group was 85, 99.6, 99.8, 100 and 100% for cattle treated 2, 6, 8, 12 and 16 weeks after infection, respectively. Data are also presented on body weight changes during the experimental period and on serum gamma-GT activity in cattle from selected groups. Triclabendazole is considered to be safer and more efficacious than currently available fasciolicides in China.
18头中国黄牛被实验性感染肝片吸虫囊蚴，并随机分为6组。5组黄牛以12毫克/千克的剂量单次口服三氯苯达唑进行治疗。尸检时，与未治疗组相比，感染后2、6、8、12和16周治疗的黄牛，其吸虫负担减少率分别为85%、99.6%、99.8%、100%和100%。还给出了实验期间体重变化以及选定组黄牛血清γ-谷氨酰转移酶活性的数据。在中国，三氯苯达唑被认为比目前可用的杀片形吸虫药更安全、更有效。
