Rapic D, Dzakula N, Sakar D, Richards R J
Department of Parasitology and Parasitic Diseases, Veterinary Faculty, University of Zagreb, Yugoslavia.
Vet Rec. 1988 Jan 16;122(3):59-62. doi: 10.1136/vr.122.3.59.
In two trials the fasciolicidal activities of triclabendazole, nitroxynil and rafoxanide were assessed in cattle naturally infected with predominantly immature stages of Fasciola hepatica. Tablets containing 900 mg triclabendazole were administered orally at a dose rate of 12 mg/kg bodyweight. Rafoxanide and nitroxynil were used at a dose rate of 10 mg/kg, rafoxanide being given orally and nitroxynil by subcutaneous injection. Based on faecal egg counts nine weeks after treatment the efficacies were calculated to be 100 per cent for triclabendazole and 95.0 per cent for nitroxynil in the first trial and 98.4 per cent for triclabendazole and 52.9 per cent for rafoxanide 15 weeks after treatment in the second trial. In the first trial five animals from each of the three groups were slaughtered and their fluke burdens counted. Compared with the untreated control group the reductions in the fluke burdens were 96.9 per cent in triclabendazole treated cattle and 76.4 per cent in the nitroxynil treated group.
在两项试验中，评估了三氯苯达唑、硝碘酚腈和雷复尼特对自然感染肝片吸虫主要为未成熟阶段的牛的杀吸虫活性。口服给予含900毫克三氯苯达唑的片剂，剂量为12毫克/千克体重。雷复尼特和硝碘酚腈的使用剂量为10毫克/千克，雷复尼特口服给药，硝碘酚腈皮下注射。根据治疗后九周的粪便虫卵计数，在第一项试验中，三氯苯达唑的疗效计算为100%，硝碘酚腈为95.0%；在第二项试验中，治疗15周后，三氯苯达唑的疗效为98.4%，雷复尼特为52.9%。在第一项试验中，对三组中的每组五头动物进行屠宰并计数其吸虫负荷。与未治疗的对照组相比，三氯苯达唑治疗的牛的吸虫负荷减少了96.9%，硝碘酚腈治疗组减少了76.4%。
