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High impact of methylation accumulation on metachronous gastric cancer: 5-year follow-up of a multicentre prospective cohort study.

作者信息

Maeda Masahiro, Nakajima Takeshi, Oda Ichiro, Shimazu Taichi, Yamamichi Nobutake, Maekita Takao, Asada Kiyoshi, Yokoi Chizu, Ando Takayuki, Yoshida Takeichi, Nanjo Sohachi, Fujishiro Mitsuhiro, Gotoda Takuji, Ichinose Masao, Ushijima Toshikazu

机构信息

Division of Epigenomics, National Cancer Center Research Institute, Tokyo, Japan.

Department of Gastrointestinal Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

出版信息

Gut. 2017 Sep;66(9):1721-1723. doi: 10.1136/gutjnl-2016-313387. Epub 2016 Dec 21.

DOI:10.1136/gutjnl-2016-313387
PMID:28003322
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5561365/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a26c/5561365/6df4b76ab38b/gutjnl-2016-313387f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a26c/5561365/6df4b76ab38b/gutjnl-2016-313387f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a26c/5561365/6df4b76ab38b/gutjnl-2016-313387f01.jpg

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Gut. 2015 Mar;64(3):388-96. doi: 10.1136/gutjnl-2014-307094. Epub 2014 Jun 2.
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Inflammation-associated cancer development in digestive organs: mechanisms and roles for genetic and epigenetic modulation.消化系统炎症相关癌症的发生发展:遗传和表观遗传调控的机制及作用。
Gastroenterology. 2012 Sep;143(3):550-563. doi: 10.1053/j.gastro.2012.07.009. Epub 2012 Jul 13.
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Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes.
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Dig Dis. 2025;43(2):158-169. doi: 10.1159/000543645. Epub 2025 Jan 17.
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MIR124-3 and NKX6-1 hypermethylation profiles accurately predict metachronous gastric lesions in a Caucasian population.MIR124-3 和 NKX6-1 高甲基化谱可准确预测高加索人群的胃同步性病变。
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