芍药苷减轻香烟烟雾诱导的大鼠慢性阻塞性肺疾病模型中的氧化应激。
Paeoniflorin Attenuated Oxidative Stress in Rat COPD Model Induced by Cigarette Smoke.
作者信息
Lin Jinpei, Xu Fei, Wang Genfa, Kong Lingwen, Luo Qingli, Lv Yvbao, Liu Jiaqi, Wei Ying, Li Lulu, Zhang Hongying, Dong Jingcheng
机构信息
Department of Integrative Medicine, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai 200040, China; The Academy of Integrative Medicine of Fudan University, Shanghai 20040, China.
出版信息
Evid Based Complement Alternat Med. 2016;2016:1698379. doi: 10.1155/2016/1698379. Epub 2016 Nov 28.
Abstract
Paeoniflorin (PF), a monoterpene glucoside, might have an effect on the oxidative stress. However, the mechanism is still unknown. In this study, we made the COPD model in Sprague-Dawley (SD) rats by exposing them to the smoke of 20 cigarettes for 1 hour/day and 6 days/week, for 12 weeks, 24 weeks, or 36 weeks. Our findings suggested that smoke inhalation can trigger the oxidative stress from the very beginning. A 24-week treatment of PF especially in the dosage of 40 mg/kg·d can attenuate oxygen stress by partially quenching reactive oxygen species (ROS) and upregulating antioxidant enzymes via an Nrf2-dependent mechanism.
摘要
芍药苷（PF）是一种单萜糖苷，可能对氧化应激有影响。然而，其机制仍不清楚。在本研究中，我们通过让Sprague-Dawley（SD）大鼠每天暴露于20支香烟的烟雾中1小时、每周6天，持续12周、24周或36周，建立了慢性阻塞性肺疾病（COPD）模型。我们的研究结果表明，吸入烟雾从一开始就会引发氧化应激。PF进行24周的治疗，尤其是剂量为40mg/kg·d时，可通过部分淬灭活性氧（ROS）并通过Nrf2依赖性机制上调抗氧化酶来减轻氧化应激。
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