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Non-coding RNAs in Exosomes: New Players in Cancer Biology.外泌体中的非编码RNA：癌症生物学中的新角色
Curr Genomics. 2015 Oct;16(5):295-303. doi: 10.2174/1389202916666150707154719.
2
MicroRNA-29 regulates high-glucose-induced apoptosis in human retinal pigment epithelial cells through PTEN.微小RNA-29通过PTEN调控高糖诱导的人视网膜色素上皮细胞凋亡。
In Vitro Cell Dev Biol Anim. 2016 Apr;52(4):419-26. doi: 10.1007/s11626-015-9990-z. Epub 2016 Jan 28.
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Non-coding RNA profiling of the developing murine lens.发育中小鼠晶状体的非编码RNA谱分析
Exp Eye Res. 2016 Apr;145:347-351. doi: 10.1016/j.exer.2016.01.010. Epub 2016 Jan 22.
4
MicroRNAs as potential biomarkers of eye diseases.微小RNA作为眼部疾病的潜在生物标志物。
Arch Soc Esp Oftalmol. 2015 Dec;90(12):604-5. doi: 10.1016/j.oftal.2015.07.016. Epub 2015 Nov 18.
5
Number of People Blind or Visually Impaired by Cataract Worldwide and in World Regions, 1990 to 2010.1990年至2010年全球及世界各地区因白内障致盲或视力受损的人数。
Invest Ophthalmol Vis Sci. 2015 Oct;56(11):6762-9. doi: 10.1167/iovs.15-17201.
6
MicroRNA-29a induces apoptosis via increasing the Bax:Bcl-2 ratio in dermal fibroblasts of patients with systemic sclerosis.微小RNA-29a通过增加系统性硬化症患者皮肤成纤维细胞中Bax与Bcl-2的比例来诱导细胞凋亡。
Autoimmunity. 2015;48(6):369-78. doi: 10.3109/08916934.2015.1030616. Epub 2015 Apr 10.
7
MicroRNA-125b inhibits lens epithelial cell apoptosis by targeting p53 in age-related cataract.微小RNA-125b通过靶向p53抑制年龄相关性白内障中晶状体上皮细胞的凋亡。
Biochim Biophys Acta. 2014 Dec;1842(12 Pt A):2439-47. doi: 10.1016/j.bbadis.2014.10.002.
8
MicroRNA expression and regulation in the uterus during embryo implantation in rat.在大鼠胚胎植入过程中子宫内 microRNA 的表达和调控。
FEBS J. 2014 Apr;281(7):1872-91. doi: 10.1111/febs.12751. Epub 2014 Mar 7.
9
Dynamic and differential regulation in the microRNA expression in the developing and mature cataractous rat lens.发育中和成熟白内障大鼠晶状体中 microRNA 表达的动态和差异调控。
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10
MicroRNA-29a-5p is a novel predictor for early recurrence of hepatitis B virus-related hepatocellular carcinoma after surgical resection.微小 RNA-29a-5p 是预测乙型肝炎病毒相关肝细胞癌术后早期复发的新标志物。
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微小RNA-29a和微小RNA-29c在早期糖尿病大鼠白内障形成中的表达及调控

Expression and regulation of microRNA-29a and microRNA-29c in early diabetic rat cataract formation.

作者信息

Sun Ying, Lu Chun-Mei, Song Zhen, Xu Ke-Ke, Wu Shu-Bin, Li Zhi-Jian

机构信息

Department of Ophthalmology, First Affiliated Hospital, Harbin Medical University, Harbin 150001, Heilongjiang Province, China; Department of Ophthalmology, Second Hospital of Heilongjiang Province, Harbin 150001, Heilongjiang Province, China.

Department of Physiology, Harbin Medical University, Harbin 150001, Heilongjiang Province, China.

出版信息

Int J Ophthalmol. 2016 Dec 18;9(12):1719-1724. doi: 10.18240/ijo.2016.12.03. eCollection 2016.

DOI:10.18240/ijo.2016.12.03
PMID:28003969
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5154982/
Abstract

AIM

To determine the role of microRNA (miRNA)-29a and miRNA-29c in the regulation of apoptosis in early rat diabetic cataract formation.

METHODS

Streptozotocin (STZ)-induced diabetic Sprague-Dawley (SD) rats were used in the study. The expression level of miRNA-29a, miRNA-29c, and BCL2-modifying factor (BMF) in lens epithelial cells (LECs) samples were measured using quantitative real-time polymerase chain reaction. Prediction algorithms of miRanda, TargetScan 6.2, and mirRDB to perform a miRNA gene network analysis were used for the potential miRNA-29a and miRNA-29c targets.

RESULTS

The miRNA-29a and miRNA-29c expression levels were all significantly lower in the control group compared to the 2 and 4wk diabetic samples (<0.01). The network analysis indicated that one miRNA-29a and miRNA-29c targets was BMF. There was significantly higher expression of BMF mRNA compared to the normal controls (<0.01).

CONCLUSION

Apoptosis occurs in rat LECs following high blood glucose exposure. It is likely that apoptosis during diabetic cataract formation involves the decreased expression of miRNA-29a and miRNA-29c and the increased expression of BMF.

摘要

目的

确定微小RNA（miRNA）-29a和miRNA-29c在大鼠早期糖尿病性白内障形成过程中对细胞凋亡调控的作用。

方法

本研究采用链脲佐菌素（STZ）诱导的糖尿病Sprague-Dawley（SD）大鼠。使用定量实时聚合酶链反应测量晶状体上皮细胞（LECs）样本中miRNA-29a、miRNA-29c和BCL2修饰因子（BMF）的表达水平。利用miRanda、TargetScan 6.2和mirRDB预测算法进行miRNA基因网络分析，以确定潜在的miRNA-29a和miRNA-29c靶标。

结果

与2周和4周糖尿病样本相比，对照组中miRNA-29a和miRNA-29c的表达水平均显著降低（<0.01）。网络分析表明，BMF是miRNA-29a和miRNA-29c的一个靶标。与正常对照组相比，BMF mRNA的表达显著更高（<0.01）。

结论

高血糖暴露后大鼠晶状体上皮细胞发生凋亡。糖尿病性白内障形成过程中的细胞凋亡可能涉及miRNA-29a和miRNA-29c表达降低以及BMF表达增加。