Pervushin N V, Nilov D K, Zhivotovsky B, Kopeina G S
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
Faculty of Medicine, M.V. Lomonosov Moscow State University, Moscow, Russia.
Cell Death Differ. 2025 Aug 23. doi: 10.1038/s41418-025-01562-z.
Members of the Bcl-2 family are essential regulators of cell fate. Some of them (proapoptotic) promote cell death, while others (antiapoptotic) support cell survival. Bcl-2 modifying factor (Bmf) is an understudied BH3-only protein of this family that is widely expressed in many normal and cancer tissues. Bmf's proapoptotic activity is essential in physiological and pathological processes, including hematopoiesis, gametogenesis, diabetes, tumorigenesis, etc. However, Bmf has remained in the shadow of other BH3-only proteins for many years. This review aims to rectify this injustice and elucidate the multifaceted functions of Bmf, its regulation, and its significance in both normal and pathological contexts.
Bcl-2家族成员是细胞命运的关键调节因子。其中一些成员（促凋亡）促进细胞死亡，而其他成员（抗凋亡）支持细胞存活。Bcl-2修饰因子（Bmf）是该家族中一个研究较少的仅含BH3结构域的蛋白质，在许多正常组织和癌组织中广泛表达。Bmf的促凋亡活性在生理和病理过程中至关重要，包括造血、配子发生、糖尿病、肿瘤发生等。然而，多年来Bmf一直处于其他仅含BH3结构域蛋白质的阴影之下。本综述旨在纠正这一不公，阐明Bmf的多方面功能、其调控机制及其在正常和病理情况下的意义。
