Mo Jing, Duan An-Li, Chan Szy-Yann, Wang Xue-Fei, Wei Wen-Bin
Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China; Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing 100730, China.
Int J Ophthalmol. 2016 Dec 18;9(12):1761-1765. doi: 10.18240/ijo.2016.12.10. eCollection 2016.
To investigate the effect of posterior scleral reinforcement (PSR) on circulation of pathologic myopia eyes with posterior staphyloma by optical coherence tomography angiography (OCTA).
The study included 30 pathologic myopia eyes with posterior staphyloma which underwent PSR (PSR group) for 6 to 18mo ago, and 30 age and myopia matched eyes without PSR surgery as control group. Macular, choriocapillaris and radial peripapillary capillary (RPC) flow density were measured by OCTA, and the measurements were compared between groups.
OCTA found no significant differences in macular flow density between PSR and control groups. For the superficial flow, whole enface flow density (WED), fovea density (FD), and parafoveal density (PD) were 46.55%±5.19% 47.29%±4.12% (=0.542), 31.45%±6.35% 31.17%±4.48% (=0.841), and 48.82%±5.66% 49.21%±4.15% (=0.756) in PSR and control groups, respectively. For the deep flow, WED, FD, and PD were 52.07%±5.78% 53.95%±4.62% (=0.168), 29.62%±6.55% 29.50%±6.38% (=0.940), and 56.93%±6.17% 58.15%±5.13% (=0.407) in PSR and control groups, respectively. The choriocapillary flow density was 61.18±3.25% in PSR group 60.88%±2.56% in control group (=0.692). Also, OCTA found no significant differences in RPCs flow density between PSR and control groups. The optic disc WED, inside disc flow density and peripapillary flow density were 48.47%±4.77% 48.11%±4.57% (=0.813), 45.47%±11.44% 46.68%±9.02% (=0.709), 54.32%±5.29% 52.47%±6.62% (=0.349) in PSR and control groups, respectively.
OCTA provides a non-invasive and quantitative approach for monitoring macular and papillary blood flow in pathologic myopia. PSR can not improve but may maintain the circulation of pathologic myopia eyes with posterior staphyloma.
通过光学相干断层扫描血管造影（OCTA）研究后巩膜加固术（PSR）对伴有后巩膜葡萄肿的病理性近视眼睛血液循环的影响。
该研究纳入了30只6至18个月前接受过PSR的伴有后巩膜葡萄肿的病理性近视眼睛（PSR组），以及30只年龄和近视程度匹配但未接受PSR手术的眼睛作为对照组。通过OCTA测量黄斑、脉络膜毛细血管和视盘周围放射状毛细血管（RPC）的血流密度，并对两组测量结果进行比较。
OCTA发现PSR组和对照组之间黄斑血流密度无显著差异。对于表层血流，PSR组和对照组的全层表面血流密度（WED）、中央凹密度（FD）和中央凹旁密度（PD）分别为46.55%±5.19% 对47.29%±4.12%（P = 0.542）、31.45%±6.35% 对31.17%±4.48%（P = 0.841）和48.82%±5.66% 对49.21%±4.15%（P = 0.756）。对于深层血流，PSR组和对照组的WED、FD和PD分别为52.07%±5.78% 对53.95%±4.62%（P = 0.168）、29.62%±6.55% 对29.50%±6.38%（P = 0.940）和56.93%±6.17% 对58.15%±5.13%（P = 0.407）。PSR组脉络膜毛细血管血流密度为61.18±3.25%，对照组为60.88%±2.56%（P = 0.692）。此外，OCTA发现PSR组和对照组之间RPC血流密度无显著差异。视盘WED、视盘内血流密度和视盘周围血流密度在PSR组和对照组分别为48.47%±4.77% 对48.11%±4.57%（P = 0.813）、45.47%±11.44% 对46.68%±9.02%（P = 0.709）、54.32%±5.29% 对52.47%±6.62%（P = 0.349）。
OCTA为监测病理性近视黄斑和视盘血流提供了一种非侵入性的定量方法。PSR不能改善但可能维持伴有后巩膜葡萄肿的病理性近视眼睛的血液循环。
