Department of Ophthalmology, Shanghai Children's Hospital, School of medicine, Shanghai Jiao Tong University, No. 355 Luding Road, Shanghai, 200062, China.
Ghent University Centre for X-Ray Tomography (UGCT), Proeftuinstraat 86/N12, 9000, Ghent, Belgium.
Sci Rep. 2024 Jul 17;14(1):16479. doi: 10.1038/s41598-024-67078-7.
We aim to observe the posterior scleral reinforcement (PSR) clinical outcomes of children with high myopia and analyze the retinal vessel alteration before and after PSR by using angiography optical coherence tomography (angio-OCT). Fifty-six pediatric participants (112 eyes) clinically diagnosed high myopia were recruited and were treated by PSR in Shanghai Children's Hospital from June 1, 2021 to May 1, 2023. The average age ranged from 5.42 to 14.83 years (mean 8.83 years) and mean follow up duration was 8.7 months (3-24 months). The axial length (AL) was significantly shortened after PSR (p < 0.05). The spherical equivalent (SE) and the best-corrected visual acuity (BCVA) were also improved without severe rejection in the follow-up. Compared with baseline, angio-OCT parafoveal vessel indices including vascular area density (VAD) and vascular skeleton density (VSD) on the superficial capillary plexus layer (SCPL), as well as VAD and vessel perimeter index (VPI) on the deep capillary plexus layer (DCPL), were significantly increased after PSR surgery (p < 0.05). VPI on the SCPL, vascular diameter index (VDI) and VSD on the DCPL were also improved without statistical difference after PSR. The VSD on SCPL, VAD on DCPL of the right eyes and the VPI on SCPL of the left eyes were significantly increased after PSR (p < 0.05). PSR surgery can shorten the AL and can stable BCVA and SE in high myopia children. The angio-OCT parameters indicated that the retinal microcirculation supply was significantly improved after PSR.
我们旨在通过血管造影光相干断层扫描（angio-OCT）观察高度近视儿童的后巩膜加固术（PSR）的临床结果，并分析 PSR 前后视网膜血管变化。2021 年 6 月 1 日至 2023 年 5 月 1 日，上海儿童医学中心共招募了 56 名临床诊断为高度近视的儿科患者（112 只眼），并对其进行 PSR 治疗。患者的平均年龄为 5.42 至 14.83 岁（平均 8.83 岁），平均随访时间为 8.7 个月（3 至 24 个月）。PSR 后眼轴（AL）明显缩短（p<0.05）。随访中，球镜等效（SE）和最佳矫正视力（BCVA）也有所提高，未出现严重排斥反应。与基线相比，PSR 术后浅层毛细血管丛（SCPL）的血管面积密度（VAD）和血管骨架密度（VSD）、深层毛细血管丛（DCPL）的 VAD 和血管周长指数（VPI）等血管指数显著增加（p<0.05）。PSR 后 SCPL 的 VPI、VDI 和 DCPL 的 VSD 也有所改善，但无统计学差异。PSR 后右眼 SCPL 的 VSD、DCPL 的 VAD 和左眼 SCPL 的 VPI 均显著增加（p<0.05）。PSR 手术可缩短 AL，稳定高度近视儿童的 BCVA 和 SE。angio-OCT 参数表明，PSR 后视网膜微循环供应明显改善。
