Ayudhya T I, Raymond C C, Dingra N N
School of Pure and Applied Sciences, Florida SouthWestern State College, Fort Myers, FL 33919, USA.
Chemistry Department, State University of New York at Oswego, Oswego, NY 13126, USA.
Dalton Trans. 2017 Jan 17;46(3):882-889. doi: 10.1039/c6dt03856e.
Carbon monoxide, although widely known as a toxic gas, has received great attention in the past few decades due to its promising role as a medical gas. Several classes of carbon monoxide releasing molecules (CORMs) have been synthesised with many of them having pharmacological activities under physiological conditions. Herein, we report the synthesis and structural characterization of the first example of amine carboxyborane that releases CO under physiological conditions without the aid of inducers. A representative compound hexamethylenetetramine carboxyborane (HMTA-CB) described here has a half-life of 2.7 days and gradually releases CO with the rate constant of 3.0 × 10 s. Its ability to promote cell growth shows the beneficial effect of slow CO release to supplement CO in small amounts over time.
一氧化碳尽管作为一种有毒气体广为人知，但在过去几十年里，由于其作为医用气体具有潜在作用而备受关注。已经合成了几类一氧化碳释放分子（CORMs），其中许多在生理条件下具有药理活性。在此，我们报告了首例在生理条件下无需诱导剂即可释放CO的胺基羧硼烷的合成及结构表征。这里描述的代表性化合物六亚甲基四胺羧硼烷（HMTA-CB）半衰期为2.7天，并以3.0×10⁻⁵ s⁻¹的速率常数逐渐释放CO。其促进细胞生长的能力表明，随着时间的推移缓慢释放CO以少量补充CO具有有益效果。
