Gao Jie, Ma Xiaojuan, Zhang Ying, Guo Ming, Shi Dazhuo
Prof. Dazhuo Shi, Department of Cardiovascular Diseases Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing100091, People's Republic of China, Tel.: +86 15010355963, E-mail:
Thromb Haemost. 2017 Feb 28;117(3):429-436. doi: 10.1160/TH16-07-0503. Epub 2016 Dec 22.
The acute cardiovascular events following thrombus formation is a primary cause of morbidity and mortality of patients with coronary artery disease (CAD). Numerous studies have shown that a prethrombotic status, which can be defined as an imbalance between the procoagulant and anticoagulant conditions, would exist for a period of time before thrombogenesis. Therefore, early diagnosis and intervention of prethrombotic status are important for reducing acute cardiovascular events. However, none of prethrombotic indicators have been identified as golden standard for diagnosis of prethrombotic status to date. MicroRNAs (miRNAs), a class of short non-coding RNAs, have been shown to be involved in pathophysiologic processes related to prethrombotic status, such as endothelial dysfunction, platelet activation, impaired fibrinolysis and elevated procoagulant factors, etc. Owing to their multiple and fine-tuning impacts on gene expression, miRNAs raise a novel understanding in the underlying mechanism of prethrombotic status. This review aims to discuss the role of miRNAs in prethrombotic status, especially the differently expressed miRNAs in CAD, which may be meaningful for developing promising diagnostic biomarkers and therapeutic strategies for CAD patients in future.
血栓形成后的急性心血管事件是冠状动脉疾病（CAD）患者发病和死亡的主要原因。大量研究表明，血栓形成前状态（可定义为促凝和抗凝状态之间的失衡）在血栓形成前会存在一段时间。因此，血栓形成前状态的早期诊断和干预对于减少急性心血管事件很重要。然而，迄今为止，尚未确定任何血栓形成前指标作为诊断血栓形成前状态的金标准。微小RNA（miRNA）是一类短的非编码RNA，已被证明参与与血栓形成前状态相关的病理生理过程，如内皮功能障碍、血小板活化、纤维蛋白溶解受损和促凝因子升高等等。由于其对基因表达具有多重和微调作用，miRNA为血栓形成前状态的潜在机制带来了新的认识。本综述旨在探讨miRNA在血栓形成前状态中的作用，尤其是CAD中差异表达的miRNA，这可能对未来开发有前景的CAD诊断生物标志物和治疗策略具有重要意义。
