格林-巴利综合征患者胫神经和腓总神经的弥散张量成像：一项可行性研究。

Diffusion Tensor Imaging of Tibial and Common Peroneal Nerves in Patients With Guillain-Barre Syndrome: A Feasibility Study.

机构信息

Department of Radiology, Zibo Central Hospital, Zibo, Shandong, P.R. China.

Department of MR, Shandong Medical Imaging Research Institute, Shandong University, Jinan, Shandong, P.R. China.

出版信息

J Magn Reson Imaging. 2019 May;49(5):1356-1364. doi: 10.1002/jmri.26324. Epub 2018 Sep 25.

DOI:10.1002/jmri.26324

PMID:30252994

Abstract

BACKGROUND

The development of a noninvasive, objective, and accurate method to assess peripheral nerve disorders in Guillain-Barre syndrome (GBS) is of clinical significance. Diffusion tensor imaging (DTI) has been used to evaluate some peripheral nerve disorders.

PURPOSE

To investigate the feasibility of DTI in evaluating the peripheral nerve disorders in patients with GBS.

STUDY TYPE

Case control.

SUBJECTS

Twenty GBS patients and 16 healthy volunteers.

FIELD STRENGTH/SEQUENCE: 3.0T, T WI-SE, T WI-SPAIR, DTI; electrophysiology.

ASSESSMENT

MRI data were analyzed by two radiologists blindly and independently. Fractional anisotropy (FA), apparent diffusion coefficient (ADC), axial diffusion coefficient (AD), and radial diffusion coefficient (RD) values of tibial nerve (TN) and common peroneal nerve (CPN) were recorded. Motor nerve conduction velocity (MCV) and motor nerve conduction amplitude of TN and CPN were recorded.

STATISTICAL TESTS

Intraclass correlation coefficient (ICC), t-test, receiver-operating characteristic (ROC), and area under the curve (AUC) analysis, Pearson correlation coefficient.

RESULTS

The FA and AD values of TN and CPN in the GBS group were significantly lower and the ADC and RD values were higher than those in the controls (P <0.05). The AUC of the FA values (0.970 for TN and 0.927 for CPN) were higher than that of the ADC, AD, and RD values. FA and AD values were positively correlated and ADC, RD values were negatively correlated with MCV and motor nerve conduction amplitude, respectively (P <0.05). The correlations between FA value and electrophysiology parameters were the highest.

DATA CONCLUSION

DTI quantitative parameters could evaluate the disorders of peripheral nerves in patients with GBS. A moderate correlation was observed between DTI and electrophysiology parameters.

LEVEL OF EVIDENCE

3 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2019;49:1356-1364.

摘要

背景

开发一种非侵入性、客观且准确的方法来评估吉兰-巴雷综合征（GBS）中的周围神经病变具有重要的临床意义。弥散张量成像（DTI）已被用于评估某些周围神经病变。

目的

探讨 DTI 评估 GBS 患者周围神经病变的可行性。

研究类型

病例对照。

受试者

20 例 GBS 患者和 16 名健康志愿者。

磁场强度/序列：3.0T，T1WI-SE，T2WI-SPAIR，DTI；电生理学。

评估

由两位放射科医生盲法独立分析 MRI 数据。记录胫神经（TN）和腓总神经（CPN）的各向异性分数（FA）、表观扩散系数（ADC）、轴扩散系数（AD）和径向扩散系数（RD）值。记录 TN 和 CPN 的运动神经传导速度（MCV）和运动神经传导幅度。

统计学检验

组内相关系数（ICC）、t 检验、受试者工作特征（ROC）和曲线下面积（AUC）分析、Pearson 相关系数。

结果

GBS 组 TN 和 CPN 的 FA 值和 AD 值明显低于对照组，ADC 值和 RD 值高于对照组（P<0.05）。FA 值（TN 为 0.970，CPN 为 0.927）的 AUC 高于 ADC、AD 和 RD 值。FA 值和 AD 值与 MCV 和运动神经传导幅度呈正相关，ADC 值和 RD 值与 MCV 和运动神经传导幅度呈负相关（P<0.05）。FA 值与电生理学参数的相关性最高。