Masuko Kayo
Health Evaluation and Promotion Center, Sanno Medical Center, Tokyo, Japan.
Clinical Research Center for Medicine, International University of Health and Welfare, Tokyo, Japan.
J Orthop Res. 2017 May;35(5):939-943. doi: 10.1002/jor.23507. Epub 2017 Mar 8.
Recent evidence suggests that common factor(s) or molecule(s) might regulate lipid and glucose metabolism, inflammation, and bone and cartilage degeneration. These findings may be particularly relevant for cases of rheumatoid arthritis, in which chronic inflammation occurs in an autoimmune context and causes the degradation of articular joints as well as insulin resistance and cardiovascular complications. Candidates for this common regulatory system include signals mediated by peroxisome proliferator-activated regulator and its response factor, angiopoietin-like 4. The expression and bioactivity of angiopoietin-like 4, an adipocytokine that was originally reported to have an angiogenic function, have been detected not only in the vascular system and adipose tissue but also in rheumatoid joints. An essential role for angiopoietin-like 4 has been established in dyslipidemia, and recent reports indicate that it may modulate bone and cartilage catabolism in rheumatoid arthritis. The enhanced expression of angiopoietin-like 4 in rheumatoid arthritis may explain the occurrence of insulin resistance, cardiovascular risk, and joint destruction, thereby suggesting that this molecule could be a potential target for anti-rheumatoid arthritis strategies. This review describes recent research on the role of angiopoietin-like 4 in chronic inflammatory conditions and rheumatoid arthritis, as well as potential therapeutic candidates. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:939-943, 2017.
最近的证据表明，某些共同的因素或分子可能调节脂质和葡萄糖代谢、炎症以及骨骼和软骨退变。这些发现可能与类风湿性关节炎的病例特别相关，在类风湿性关节炎中，慢性炎症在自身免疫的背景下发生，并导致关节退化以及胰岛素抵抗和心血管并发症。这种共同调节系统的候选分子包括由过氧化物酶体增殖物激活调节因子及其反应因子介导的信号、血管生成素样4。血管生成素样4是一种最初报道具有血管生成功能的脂肪细胞因子，其表达和生物活性不仅在血管系统和脂肪组织中被检测到，在类风湿关节中也被检测到。血管生成素样4在血脂异常中已被证实发挥重要作用，最近的报道表明它可能调节类风湿性关节炎中的骨骼和软骨分解代谢。血管生成素样4在类风湿性关节炎中的表达增强可能解释了胰岛素抵抗、心血管风险和关节破坏的发生，从而表明该分子可能是抗类风湿性关节炎策略的潜在靶点。这篇综述描述了关于血管生成素样4在慢性炎症性疾病和类风湿性关节炎中的作用以及潜在治疗候选物的最新研究。©2017骨科学研究协会。由威利期刊公司出版。《矫形外科学研究》35:939 - 943，2017年。
