在商业膳食补充剂中鉴定出一种新型他达拉非类似物：异丙基去甲他达拉非。
Identification of a new tadalafil analogue in commercial dietary supplements: isopropylnortadalafil.
作者信息
Park Han Na, Lee Ji Hyun, Park Sung-Kwan, Lee Jongkook, Baek Sun Young
机构信息
a Advanced Analysis Team, Toxicological Evaluation and Research Department , National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety , Cheongju-si , Chungcheongbuk-do , South Korea.
b College of Pharmacy , Kangwon National University , Chuncheon , Gangwon-do , South Korea.
出版信息
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2017 Feb;34(2):162-169. doi: 10.1080/19440049.2016.1263878. Epub 2016 Dec 22.
A new tadalafil analogue was found in a commercial dietary supplement for enhancing sexual performance. The compound was detected by a high-performance liquid chromatography-diode array detector (HPLC-DAD). The analogue was isolated using semi-preparative HPLC, and its accurate mass was established by two LC-high-resolution-mass spectrometers (LC-HRMS). The structure was determined by nuclear magnetic resonance (NMR) spectroscopy. The accurate mass of the compound corresponded to a molecular formula of CHNO. The compound was identified as a structural analogue of tadalafil in which the N-methyl group of tadalafil was replaced with an N-isopropyl group. We have named the new analogue isopropylnortadalafil and it is first reported herein.
在一种用于增强性功能的商业膳食补充剂中发现了一种新型他达拉非类似物。该化合物通过高效液相色谱 - 二极管阵列检测器（HPLC - DAD）检测到。使用半制备型HPLC分离该类似物，并通过两台液相色谱 - 高分辨率质谱仪（LC - HRMS）确定其精确质量。通过核磁共振（NMR）光谱确定结构。该化合物的精确质量对应于分子式CHNO。该化合物被鉴定为他达拉非的结构类似物，其中他达拉非的N - 甲基被N - 异丙基取代。我们将这种新类似物命名为异丙基去甲他达拉非，本文首次报道。
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