在一种补充剂产品中鉴定出一种新型他达拉非类似物。
Identification of a new type tadalafil analogue in a supplement product.
作者信息
Huang Yen-Chun, Lee Hui-Chun, Lin Yun-Lian, Tsai Chia-Fen, Cheng Hwei-Fang
机构信息
a Chemical Lab , Super Laboratory Company Limited , New Taipei City , Taiwan (R.O.C).
b Division of Research and Analysis , Taiwan Food and Drug Administration , Taipei City , Taiwan(R.O.C).
出版信息
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2018 Jul;35(7):1233-1237. doi: 10.1080/19440049.2018.1459052. Epub 2018 May 30.
A novel compound structurally similar to tadalafil was found in a dietary supplement by adulterants screening test and isolated by column chromatography. After analysis by accurate mass, nuclear magnetic resonance (NMR) and X-ray, the structure of this novel tadalafil analogue was determined as (5R, 16R)-5-(1,3-benzodioxol-5-yl)-2- (3-ethypentan-3-yl)-15,16-dihydro(1H-imidazo[1,5-a]pyrido)[3,4-b]indol-1,3-dion.
通过掺假筛选试验在一种膳食补充剂中发现了一种结构与他达拉非相似的新型化合物，并通过柱色谱法进行分离。经精确质量分析、核磁共振（NMR）和X射线分析后，确定这种新型他达拉非类似物的结构为(5R, 16R)-5-(1,3-苯并二氧杂环戊烯-5-基)-2-(3-乙基戊-3-基)-15,16-二氢(1H-咪唑并[1,5-a]吡啶并)[3,4-b]吲哚-1,3-二酮。
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