新型吡啶基介离子 1,3-偶极子的开发与环加成反应活性。
Development and Cycloaddition Reactivity of a New Class of Pyridine-Based Mesoionic 1,3-Dipole.
机构信息
Department of Chemistry, McGill University, 801 Sherbrooke St. W, Montreal, Quebec, H3A 0B8, Canada.
出版信息
Angew Chem Int Ed Engl. 2017 May 22;56(22):6078-6082. doi: 10.1002/anie.201609726. Epub 2016 Dec 22.
PMID:28004875
Abstract
We describe here the development and structural characterization of a new type of mesoionic 1,3-dipole, which can be generated in the one-step reaction of imines with pyridine- or quinoline-based acid chlorides. Coupling the formation of these dipoles with alkyne cycloaddition can open a general and modular route to synthesize indolizines from combinations of available and diversifiable building blocks.
摘要
我们在这里描述了一种新型介离子 1,3-偶极子的开发和结构特征，它可以通过亚胺与吡啶或喹啉基酰氯的一步反应生成。将这些偶极子的形成与炔烃环加成相结合，可以为从可用和多样化的构建块组合中合成吲哚嗪开辟一条通用和模块化的途径。
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