Kaschwich Mark, Behrendt Christian A, Tsilimparis Nikolaos, Kölbel Tilo, Wipper Sabine H, Debus Eike S
Department of Vascular Medicine, German Aortic Center Hamburg, University Heart Center, University Hospital Eppendorf, Hamburg, Germany -
Department of Vascular Medicine, German Aortic Center Hamburg, University Heart Center, University Hospital Eppendorf, Hamburg, Germany.
J Cardiovasc Surg (Torino). 2017 Apr;58(2):313-320. doi: 10.23736/S0021-9509.16.09798-6. Epub 2016 Dec 22.
Acute aortic thrombosis (AAT) is a rare life threatening event that leads to a sudden occlusion of the aorta. The mortality and morbidity of AAT is still high despite modern surgical techniques. Usually it is the result of a large saddle embolus to the aortic bifurcation, in situ thrombosis of an atherosclerotic aorta or acute occlusion of an abdominal aortic aneurysm. Clinical symptoms depend on the level of the aortic occlusion and can be mistaken for a stroke or similar neurological disease. The combination of age and advanced cardiac disease seems to be significant risks factors for AAT. In patients who have no cardiac or vascular disease this catastrophic event is very rare and is mostly due to hypercoagulable disorders. Revascularization of the ischemic organ/limb as soon as possible is the major aim in the therapy of AAT to avoid further ischemic damage. Surgical reperfusion is the first line approach. If the accepting clinic has no facilities for an immediate surgical intervention it is of primary importance that these patients should be referred to an appropriate center for further management. Paradox seems the fact that most of the patients die as a consequence of reperfusion injury/postperfusion syndrome that occurs after revascularization of acute ischemic limbs.
急性主动脉血栓形成(AAT)是一种罕见的危及生命的事件,可导致主动脉突然闭塞。尽管有现代外科技术,AAT的死亡率和发病率仍然很高。通常它是由一个大的鞍状栓子栓塞至主动脉分叉、动脉粥样硬化性主动脉原位血栓形成或腹主动脉瘤急性闭塞所致。临床症状取决于主动脉闭塞的部位,可能被误诊为中风或类似的神经系统疾病。年龄和晚期心脏病似乎是AAT的重要危险因素。在没有心脏或血管疾病的患者中,这种灾难性事件非常罕见,主要是由于高凝状态。尽快使缺血的器官/肢体恢复血运是AAT治疗的主要目标,以避免进一步的缺血损伤。手术再灌注是一线治疗方法。如果接收诊所没有立即进行手术干预的设施,那么将这些患者转诊至合适的中心进行进一步治疗至关重要。矛盾的是,大多数患者死于急性缺血肢体再血管化后发生的再灌注损伤/灌注后综合征。