Hood Michael A, Murtha Yvonne M, Della Rocca Gregory J, Stannard James P, Volgas David A, Crist Brett D
Department of Orthopaedic Surgery, University of Missouri, Columbia, MO.
Am J Orthop (Belle Mead NJ). 2016 Nov/Dec;45(7):E522-E526.
Low levels of serum vitamin D have been linked to numerous musculoskeletal and nonmusculoskeletal conditions. Vitamin D deficiency appears relatively high among various patient subpopulations, including patients with fracture nonunion. We conducted a retrospective study to determine the prevalence of vitamin D deficiency and insufficiency in a large population of patients with orthopedic trauma. The study included all patients who were over age 18 years, had no risk factors for vitamin D deficiency, and were treated for an acute fracture at a Level 1 trauma center. Between January 2009 and September 2010, 889 trauma patients had recorded serum 25-hydroxyvitamin D levels. Overall prevalence of combined vitamin D deficiency/insufficiency was 77%; prevalence of vitamin D deficiency alone was 39%. There were no statistically significant (P < .05) age or sex differences among the population. There did not appear to be a seasonal difference. Vitamin D deficiency and insufficiency in acute orthopedic trauma patients appear very common. Further investigation is needed to fully understand the clinical significance.
血清维生素D水平低与多种肌肉骨骼和非肌肉骨骼疾病有关。在包括骨折不愈合患者在内的各种患者亚群中，维生素D缺乏症的发生率似乎相对较高。我们进行了一项回顾性研究，以确定大量骨科创伤患者中维生素D缺乏和不足的患病率。该研究纳入了所有年龄超过18岁、无维生素D缺乏风险因素且在一级创伤中心接受急性骨折治疗的患者。在2009年1月至2010年9月期间，889名创伤患者记录了血清25-羟基维生素D水平。维生素D缺乏/不足合并症的总体患病率为77%；单纯维生素D缺乏的患病率为39%。该人群中年龄或性别差异无统计学意义（P < 0.05）。似乎没有季节性差异。急性骨科创伤患者中维生素D缺乏和不足似乎非常普遍。需要进一步研究以充分了解其临床意义。
