Jabbarpoor Bonyadi Mohammad Hossein, Yaseri Mehdi, Bonyadi Mortaza, Soheilian Masoud
Ocular Tissue Engineering Research Center, Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Pasdaran Ave, Boustan 9th street, Tehran, Iran.
Department of Biostatistics and Epidemiology, Tehran University of Medical Sciences, Tehran, Iran.
Int Ophthalmol. 2017 Dec;37(6):1397-1409. doi: 10.1007/s10792-016-0413-2. Epub 2016 Dec 22.
To compare the published results of studies on the genotype association of ARMS2/LOC387715 A69S, CFH Y402H, and CFH I62V in cases diagnosed as retinal angiomatous proliferation (RAP) versus neovascular age-related macular degeneration (AMD) or healthy controls.
Heterogeneity of studies was evaluated using Cochran's Q test and I-square index. To modify the heterogeneity in the variables, we used random effects model. Meta-analysis was performed using STATA.
Four studies were included with 1076 neovascular AMD patients, 222 RAP cases, and 2276 control subjects. Pooled overall odds ratios for RAP/AMD were 1.15 (95% CI 0.60-2.18) for GT versus GG, 3.52 (95% CI 1.25-9.91) for TT versus GG ARMS2, 0.98 (95% CI 0.22-4.29) for GA versus AA, 1.00 (95% CI 0.25-4.02) for GG versus AA CFHI62V, 0.57 (95% CI 0.35-0.93) for CT versus TT CFH Y402H, and 0.40 (95% CI 0.22-0.74) for CC versus TT CFH Y402H. Regression analysis showed that ARMS2 TT genotype has a statistically significant effect on RAP versus AMD compared to CFH genotypes (P < 0.001).
This meta-analysis disclosed a stronger effect of ARMS2 genotypes in RAP cases compared with CFH Y402H and I62V genotypes.
比较已发表的关于诊断为视网膜血管瘤样增生（RAP）与新生血管性年龄相关性黄斑变性（AMD）或健康对照者中ARMS2/LOC387715 A69S、CFH Y402H和CFH I62V基因分型关联研究的结果。
使用 Cochr an's Q检验和I方指数评估研究的异质性。为了改变变量中的异质性，我们使用随机效应模型。使用STATA进行荟萃分析。
纳入四项研究，包括1076例新生血管性AMD患者、222例RAP病例和2276例对照受试者。RAP/AMD的合并总体优势比为：GT与GG相比为1.15（95%可信区间0.60 - 2.18），ARMS2的TT与GG相比为3.52（95%可信区间1.25 - 9.91），GA与AA相比为0.98（95%可信区间0.22 - 4.29），CFHI62V的GG与AA相比为1.00（95%可信区间0.25 - 4.02），CFH Y402H的CT与TT相比为0.57（95%可信区间0.35 - 0.93），CFH Y402H的CC与TT相比为0.40（95%可信区间0.22 - 0.74）。回归分析表明，与CFH基因型相比，ARMS2 TT基因型对RAP与AMD具有统计学显著影响（P < 0.001）。
这项荟萃分析表明，与CFH Y402H和I62V基因型相比，ARMS2基因型在RAP病例中的作用更强。
