Ocular Tissue Engineering Research Center, Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of biostatistics and epidemiology, Tehran University of Medical Sciences, Tehran, Iran.
Acta Ophthalmol. 2018 Mar;96(2):e105-e110. doi: 10.1111/aos.13494. Epub 2017 Jun 8.
To pool the results of published data regarding association of ARMS2/LOC387715 A69S, CFH Y402H and CFH I62V genotypes with age-related macular degeneration (AMD) with and without reticular pseudodrusen (RPD). The results of this pooled data used to estimate the contribution of each of these genes in the pathogenesis of RPD. Heterogeneity of studies was evaluated using Cochran Q-test and I index. To modify the heterogeneity in the variables, we used the random effects model. Meta-analysis was performed using STATA. Odds ratio (OR) of genotypes in each study was calculated. Six studies of AMD with RPD and AMD without RPD cases included in this analysis. Analysis of pooled data showed that risk genotypes frequency of ARMS2 A69S was significantly different between AMD with RPD and AMD without RPD [OR = 1.82, 95% confidence interval (CI): 1.26-2.63 for GT versus GG ARMS2 A69S; OR = 2.40, 95% CI: 1.50-3.84 for TT versus GG ARMS2 A69S]. Further analysis also showed that the risk genotype frequency of CFH Y402H was not significantly different between these two groups (OR = 1.02, 95% CI: 0.69-1.50 for CT versus TT CFH Y402H; OR = 1.09, 95% CI: 0.74-1.60 for CC versus TT CFH Y402H). Comparison of above-mentioned ORs revealed statistically higher values for GT and TT genotypes of ARMS2 A69S compared with CFH Y402H genotypes (p = 0.011, p = 0.014, respectively).Our analysis showed stronger contribution of ARMS2 in AMD with RPD group versus AMD without RPD group, in comparison with CFH genotypes.
汇总已发表的关于 ARMS2/LOC387715 A69S、CFH Y402H 和 CFH I62V 基因型与伴或不伴网状假性脉络膜病变（RPD）的年龄相关性黄斑变性（AMD）关联性的研究结果。使用这些汇总数据来评估这些基因在 RPD 发病机制中的作用。使用 Cochran Q 检验和 I 指数评估研究的异质性。为了修正变量的异质性，我们使用了随机效应模型。使用 STATA 进行荟萃分析。计算每个研究中基因型的优势比（OR）。本分析纳入了伴 RPD 和不伴 RPD 的 AMD 共 6 项研究。汇总数据分析显示，ARMS2 A69S 风险基因型的频率在伴 RPD 和不伴 RPD 的 AMD 之间存在显著差异[OR=1.82，95%置信区间（CI）：1.26-2.63，GT 与 GG ARMS2 A69S；OR=2.40，95% CI：1.50-3.84，TT 与 GG ARMS2 A69S]。进一步分析还显示，CFH Y402H 两种基因型的频率在这两组之间无显著差异（OR=1.02，95% CI：0.69-1.50，CT 与 TT CFH Y402H；OR=1.09，95% CI：0.74-1.60，CC 与 TT CFH Y402H）。上述 OR 的比较显示，与 CFH Y402H 基因型相比，ARMS2 A69S 的 GT 和 TT 基因型具有更高的统计学值（p=0.011，p=0.014）。我们的分析显示，与 CFH 基因型相比，ARMS2 在伴 RPD 的 AMD 组中的作用强于不伴 RPD 的 AMD 组。
