Berg A O, Melle I, Zuber V, Simonsen C, Nerhus M, Ueland T, Andreassen O A, Sundet K, Vaskinn A
a NORMENT - K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine , University of Oslo , Oslo , Norway.
b NORMENT, Division of Mental Health and Addiction , Oslo University Hospital , Oslo , Norway.
Cogn Neuropsychiatry. 2017 Jan;22(1):39-52. doi: 10.1080/13546805.2016.1259998. Epub 2016 Dec 22.
Abstract thinking is important in modern understanding of neurocognitive abilities, and a symptom of thought disorder in psychosis. In patients with psychosis, we assessed if socio-developmental background influences abstract thinking, and the association with executive functioning and clinical psychosis symptoms.
Participants (n = 174) had a diagnosis of psychotic or bipolar disorder, were 17-65 years, intelligence quotient (IQ) > 70, fluent in a Scandinavian language, and their full primary education in Norway. Immigrants (N = 58) were matched (1:2) with participants without a history of migration (N = 116). All participants completed a neurocognitive and clinical assessment. Socio-developmental background was operationalised as human developmental index (HDI) of country of birth, at year of birth. Structural equation modelling was used to assess the model with best fit.
The model with best fit, χ = 96.591, df = 33, p < .001, confirmed a significant indirect effect of HDI scores on abstract thinking through executive functioning, but not through clinical psychosis symptoms.
This study found that socio-developmental background influences abstract thinking in psychosis by indirect effect through executive functioning. We should take into account socio-developmental background in the interpretation of neurocognitive performance in patients with psychosis, and prioritise cognitive remediation in treatment of immigrant patients.
抽象思维在现代对神经认知能力的理解中很重要，也是精神病思维障碍的一种症状。在精神病患者中，我们评估了社会发展背景是否会影响抽象思维，以及它与执行功能和临床精神病症状之间的关联。
参与者（n = 174）被诊断为患有精神病或双相情感障碍，年龄在17至65岁之间，智商（IQ）> 70，能流利使用一种斯堪的纳维亚语言，且在挪威接受了完整的小学教育。移民（N = 58）与无移民史的参与者（N = 116）进行了匹配（1:2）。所有参与者都完成了神经认知和临床评估。社会发展背景被定义为出生国家在出生年份的人类发展指数（HDI）。采用结构方程模型来评估拟合度最佳的模型。
拟合度最佳的模型，χ = 96.591，df = 33，p <.001，证实了HDI分数通过执行功能对抽象思维有显著的间接影响，但通过临床精神病症状则没有。
本研究发现社会发展背景通过执行功能的间接影响来影响精神病患者的抽象思维。在解释精神病患者的神经认知表现时，我们应考虑社会发展背景，并在治疗移民患者时优先进行认知矫正。
