Scharkoff H, Merkel S, Kessler G
Bezirksstelle für Lungenkrankheiten und Tuberkulose, Cottbus, DDR.
Z Erkr Atmungsorgane. 1989;173(1):50-9.
In 3,296 school-leavers (girls and boys aged 16 years with preceding BCG-vaccination as newborns and without boosting by tuberculin-testing or revaccination during the meantime) simultaneously with compulsory BCG-revaccination tuberculin testing with 2 TU PPD Dessau + Tween 80 was performed in 3 regions of the GDR (Cottbus, Erfurt, Neubrandenburg) in the 2nd half of 1985 and in the 1st quarter of 1986. Sensitivity to tuberculin was found in 7.3% considering reactions with greater than or equal to 6 mm induration as positive, and in 2.9% considering reactions with greater than or equal to 10 mm only. Positive reactions greater than or equal to 6 mm include remaining allergy caused by BCG and non-specific tuberculin sensitivity while a reaction limit greater than or equal to 10 mm is suitable to define tuberculosis infection prevalence. In contrast to studies performed 1973 and 1979 in the same territories a significant decrease in tuberculin sensitivity was evident (43.8% positive reactions (greater than or equal to 6 mm) in 1973 and 11.7% in 1979). The acceptability of "direct" BCG-revaccination has been estimated by evaluation of local reactions 4 weeks after vaccination in 2,123 school-leavers. The ulceration rate in tuberculin positive adolescents was significantly higher than in tuberculin negative. It showed highly significant decrease in comparison with 1979.
1985年下半年和1986年第一季度，在民主德国的三个地区（科特布斯、爱尔福特、新勃兰登堡），对3296名离校学生（16岁的男孩和女孩，出生时接种过卡介苗，在此期间未通过结核菌素试验或复种进行加强免疫）同时进行了强制性卡介苗复种，并使用2 TU PPD德绍+吐温80进行结核菌素试验。以硬结直径大于或等于6毫米的反应为阳性时，结核菌素敏感性为7.3%；仅以硬结直径大于或等于10毫米的反应为阳性时，结核菌素敏感性为2.9%。大于或等于6毫米的阳性反应包括卡介苗引起的残留过敏和非特异性结核菌素敏感性；而大于或等于10毫米的反应界限适用于确定结核感染患病率。与1973年和1979年在同一地区进行的研究相比，结核菌素敏感性明显下降（1973年阳性反应（大于或等于6毫米）为43.8%，1979年为1,17%）通过对2123名离校学生接种疫苗4周后的局部反应进行评估，估计了“直接”卡介苗复种的可接受性。结核菌素阳性青少年的溃疡率明显高于结核菌素阴性青少年。与1979年相比，溃疡率显著下降。
