Trnka L, Danková D
Forschungsnstitut für Tuberkulose und Lungenkrankheiten Prag/CSSR.
Z Erkr Atmungsorgane. 1989;173(1):60-2.
With the steadily declining risk of tuberculosis infection in CSR the question arose whether vaccination of infants remains worthwhile considering not only resources spent but also complications to vaccination vis-a-vis benefits derived. A prospective study has been designed in which BCG vaccination of newborns is discontinued in an area with 30,000 newborns yearly. In the period from April 1, 1986 to January 31, 1988 there were not vaccinated 43,428 children (84.8% of the newborns). The collaboration of mothers was good. The one year old non-vaccinated children were tested with 2 TU PPD RT 23 with Tween 80. The distribution of positive tuberculin reactions appears unimodal, relatively large reactions being absent. 8 children had reactions with 6 or more mm induration. That corresponds to a risk of infection of 0.04%. The project continues in the research area and might be extended to another area.
随着社区综合防治中结核病感染风险稳步下降，出现了一个问题，即考虑到不仅有疫苗接种所耗费的资源，还有接种疫苗的并发症与所获益处的对比，婴儿接种疫苗是否仍有价值。已设计了一项前瞻性研究，在一个每年有30000名新生儿的地区停止对新生儿接种卡介苗。在1986年4月1日至1988年1月31日期间，43428名儿童（占新生儿的84.8%）未接种疫苗。母亲们的配合良好。对1岁未接种疫苗的儿童用2个结核菌素单位的PPD RT 23加吐温80进行检测。结核菌素阳性反应的分布呈单峰型，没有相对较大的反应。8名儿童出现硬结6毫米或更大的反应。这相当于感染风险为0.04%。该项目在研究区域继续进行，可能会扩展到另一个地区。
