Department of Zoology, University of Madras, Guindy Campus, Chennai 600025, India.
Department of Zoology, University of Madras, Guindy Campus, Chennai 600025, India.
Biomed Pharmacother. 2017 Feb;86:232-241. doi: 10.1016/j.biopha.2016.11.141. Epub 2016 Dec 19.
Low vision and blindness are important health problems that affect millions of people throughout the world. The most common and important pathologies are diabetic retinopathy, age-related macular degeneration, glaucoma as well as cataracts. The latter consists of an opacification of the lens of the eye which impedes the passage of light and represents one of the most important causes of vision loss. Among the risk factors for cataract development, there are life-style factors such as the use of tobacco, abuse of alcohol and unhealthy diet. In light of this, dietary components that possess anti-oxidant activity, such as polyphenols for instance, can be considered good candidates for human studies in the prevention and or treatment of such diseases. Among dietary components, the antioxidant capacity of certain polyphenols is well known, and these could be good candidates. In this review we focus our attention on the current scientific literature regarding to the effects of resveratrol on cataracts and other ocular diseases, along with its potential mechanism/s of action. A large number of preclinical studies support the involvement of resveratrol in clinical trials for the prevention and treatment of eye diseases induced by oxidative stress and inflammation, such as age-related cataract.
低视力和失明是影响全球数百万人的重要健康问题。最常见和最重要的病理学是糖尿病视网膜病变、年龄相关性黄斑变性、青光眼以及白内障。后者是眼睛晶状体的混浊，阻碍了光线的通过，是视力丧失的最重要原因之一。在白内障发展的危险因素中，有生活方式因素，如吸烟、酗酒和不健康的饮食。鉴于此，具有抗氧化活性的膳食成分，如多酚等，可以被认为是人类预防和/或治疗此类疾病的良好候选物。在膳食成分中，某些多酚的抗氧化能力是众所周知的，它们可能是很好的候选物。在这篇综述中，我们关注了有关白藜芦醇对白内障和其他眼部疾病的影响及其潜在作用机制的当前科学文献。大量的临床前研究支持白藜芦醇在预防和治疗氧化应激和炎症引起的眼部疾病（如年龄相关性白内障）的临床试验中的应用。
