胎儿坐骨神经的功能与结构显微解剖学
Functional and structural microanatomy of the fetal sciatic nerve.
作者信息
Creze Maud, Zaitouna Mazen, Krystel Nyangoh Timoh, Diallo Djibril, Lebacle Cédric, Bellin Marie-France, Ducreux Denis, Benoit Gérard, Bessede Thomas
机构信息
U1195, INSERM, University of Paris Sud, France.
Department of Radiology, University of Paris Sud, University Hospital Bicêtre, AP-HP, France.
出版信息
Muscle Nerve. 2017 Oct;56(4):787-796. doi: 10.1002/mus.25531. Epub 2017 Apr 6.
INTRODUCTION
The ultrastructure of a nerve has implications for surgical nerve repair. The aim of our study was to characterize the fascicular versus fibrillar anatomy and the autonomic versus somatic nature of the fetal sciatic nerve (SN).
METHODS
Immunohistochemistry for vesicular acetylcholine transporter, tyrosine hydroxylase, and peripheral myelin protein 22 was performed to identify cholinergic, adrenergic, and somatic axons, respectively, in the human fetal SN. Two-dimensional (2D) analysis and 3D reconstructions were performed.
RESULTS
The fetal SN is composed of one-third stromal tissue and two-thirds neural tissue. Autonomic fibers are predominant over somatic fibers within the neural tissue. The distribution of somatic fibers is initially random, but then become topographically organized after intra- and interfascicular rearrangements have occurred within the nerve.
CONCLUSIONS
The fetal model presents limitations but enables illustration of the nature of the nerve fibers and the 3D fascicular anatomy of the SN. Muscle Nerve 56: 787-796, 2017.
引言
神经的超微结构对手术神经修复具有重要意义。我们研究的目的是描述胎儿坐骨神经（SN）的束状与纤维状解剖结构以及自主神经与躯体神经的性质。
方法
进行了囊泡乙酰胆碱转运体、酪氨酸羟化酶和外周髓鞘蛋白22的免疫组织化学检测，分别以鉴定人胎儿SN中的胆碱能、肾上腺素能和躯体轴突。进行了二维（2D）分析和三维重建。
结果
胎儿SN由三分之一的间质组织和三分之二的神经组织组成。在神经组织中，自主神经纤维比躯体神经纤维占优势。躯体纤维的分布最初是随机的，但在神经内束内和束间重排发生后，会按局部解剖学方式组织起来。
结论
胎儿模型存在局限性，但能够阐明神经纤维的性质和SN的三维束状解剖结构。《肌肉与神经》56: 787 - 796, 2017年。
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