Medeiros Carla S, Giacomin Natalia T, Bueno Renata L, Ghanem Ramon C, Moraes Haroldo V, Santhiago Marcony R
From the Department of Ophthalmology (Medeiros, Giacomin, Santhiago), University of São Paulo, São Paulo, the Sadalla Amin Ghanem Eye Hospital (Bueno, Ghanem), Joinville, and the Department of Ophthalmology (Moraes, Santhiago), Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
From the Department of Ophthalmology (Medeiros, Giacomin, Santhiago), University of São Paulo, São Paulo, the Sadalla Amin Ghanem Eye Hospital (Bueno, Ghanem), Joinville, and the Department of Ophthalmology (Moraes, Santhiago), Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
J Cataract Refract Surg. 2016 Dec;42(12):1826-1835. doi: 10.1016/j.jcrs.2016.11.028.
Corneal collagen crosslinking (CXL) is an approach used to increase the biomechanical stability of the stromal tissue. Over the past 10 years, it has been used to halt the progression of ectatic diseases. According to the photochemical law of reciprocity, the same photochemical effect is achieved with reduced illumination time and correspondingly increased irradiation intensity. Several new CXL devices offer high ultraviolet-A irradiation intensity with different time settings. The main purpose of this review was to discuss the current use of different protocols of accelerated CXL and compare the efficacy and safety of accelerated CXL with the efficacy and safety of the established conventional method. Accelerated CXL proved to be safe and effective in halting progression of corneal ectasia. Corneal shape responses varied considerably, as did the demarcation line at different irradiance settings; the shorter the exposure time, the more superficial the demarcation line.
Dr. Santhiago is a consultant to Ziemer Ophthalmic Systems AG and Alcon Laboratories, Inc. None of the authors has a financial or proprietary interest in any material or method mentioned.
角膜胶原交联（CXL）是一种用于增强基质组织生物力学稳定性的方法。在过去10年中，它已被用于阻止扩张性疾病的进展。根据互易光化学定律，在光照时间减少而相应地照射强度增加的情况下可实现相同的光化学效应。几种新型CXL设备提供具有不同时间设置的高紫外线-A照射强度。本综述的主要目的是讨论当前加速CXL不同方案的应用，并比较加速CXL与既定传统方法的疗效和安全性。加速CXL在阻止角膜扩张进展方面被证明是安全有效的。角膜形状反应差异很大，不同辐照设置下的分界线也是如此；暴露时间越短，分界线越浅。
圣地亚哥博士是齐默眼科系统股份公司和爱尔康实验室公司的顾问。没有作者对文中提及的任何材料或方法拥有财务或专有权益。
