哺乳动物中经典 PRC1 复合物的组成和功能多样性。
Compositional and functional diversity of canonical PRC1 complexes in mammals.
机构信息
Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, 201 S. University St., West Lafayette, IN 47907, USA.
Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, 201 S. University St., West Lafayette, IN 47907, USA; Purdue University Center for Cancer Research, 201 S. University St., West Lafayette, IN 47907, USA.
出版信息
Biochim Biophys Acta Gene Regul Mech. 2017 Feb;1860(2):233-245. doi: 10.1016/j.bbagrm.2016.12.006. Epub 2016 Dec 20.
The compositional complexity of Polycomb Repressive Complex 1 (PRC1) increased dramatically during vertebrate evolution. What is considered the "canonical" PRC1 complex consists of four subunits originally identified as regulators of body segmentation in Drosophila. In mammals, each of these four canonical subunits consists of two to six paralogs that associate in a combinatorial manner to produce over a hundred possible distinct PRC1 complexes with unknown function. Genetic studies have begun to define the phenotypic roles for different PRC1 paralogs; however, relating these phenotypes to unique biochemical and transcriptional function for the different paralogs has been challenging. In this review, we attempt to address how the compositional diversity of canonical PRC1 complexes relates to unique roles for individual PRC1 paralogs in transcriptional regulation. This review focuses primarily on PRC1 complex composition, genome targeting, and biochemical function.
多梳抑制复合物 1（PRC1）在脊椎动物进化过程中的组成复杂性显著增加。被认为是“典型”的 PRC1 复合物由最初在果蝇中被鉴定为体节调节因子的四个亚基组成。在哺乳动物中，这四个典型的亚基中的每一个都由两个到六个同源物组成，它们以组合的方式结合在一起，产生了一百多种可能的具有未知功能的独特 PRC1 复合物。遗传研究已经开始定义不同 PRC1 同源物的表型作用；然而，将这些表型与不同同源物独特的生化和转录功能联系起来一直具有挑战性。在这篇综述中，我们试图探讨典型的 PRC1 复合物组成如何与单个 PRC1 同源物在转录调控中的独特作用相关。这篇综述主要集中在 PRC1 复合物组成、基因组靶向和生化功能上。
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